PMID: 11904594Mar 21, 2002Paper

Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo

American Journal of Obstetrics and Gynecology
Irene GeorgakoudiMichael S Feld

Abstract

The objective of this study was to assess the potential of 3 spectroscopic techniques (intrinsic fluorescence, diffuse reflectance, and light scattering) individually and in combination (trimodal spectroscopy) for the detection of cervical squamous intraepithelial lesions. The study was conducted with 44 patients who underwent colposcopy for the evaluation of an abnormal Papanicolaou smear. Fluorescence and reflectance spectra were collected from colposcopically normal and abnormal sites and analyzed to extract quantitative information about tissue biochemistry and morphologic condition. This information was compared with histopathologic classification, and diagnostic algorithms were developed and validated with the use of logistic regression and cross-validation. Diagnostically significant differences exist in the composition of fluorescing biochemicals, the scattering properties, and the epithelial cell nuclear morphology of cervical squamous intraepithelial lesions and non-squamous intraepithelial lesions. Trimodal spectroscopy is a superior tool for the detection of cervical squamous intraepithelial lesions than any 1 of the techniques alone. Trimodal spectroscopy has the potential to improve the in vivo detection of precan...Continue Reading

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Citations

Jun 6, 2009·European Biophysics Journal : EBJ·E BogomolnyM Huleihel
Jan 15, 2009·Nature Reviews. Cancer·Nadhi Thekkek, Rebecca Richards-Kortum
Oct 11, 2008·Tissue Engineering. Part B, Reviews·Irene GeorgakoudiDavid L Kaplan
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ina PavlovaAnn Gillenwater
Aug 29, 2012·Cancer Prevention Research·Mark C PierceRebecca Richards-Kortum
May 2, 2009·The Review of Scientific Instruments·Obrad R SćepanovićMichael S Feld
Mar 11, 2006·Journal of Biomedical Optics·Nena M MarínRebecca Richards-Kortum
May 6, 2006·Journal of Biomedical Optics·Obrad R SćepanovićMichael S Feld
Jan 11, 2007·Journal of Biomedical Optics·Jonathan M LevittIrene Georgakoudi
Nov 13, 2007·Journal of Biomedical Optics·Wendy A WellsJames M Crawford
Nov 22, 2008·Journal of Biomedical Optics·Shuangmu ZhuoShusen Xie
Jan 7, 2009·Journal of Biomedical Optics·Crystal Redden WeberRebecca Richards-Kortum
May 2, 2009·Journal of Biomedical Optics·Condon LauMichael Feld
Sep 4, 2009·Journal of Biomedical Optics·Jelena MirkovicKamran Badizadegan
Nov 9, 2010·Journal of Biomedical Optics·Vadivel MasilamaniBelavendra Antonisamy
Jan 5, 2011·Journal of Biomedical Optics·Ashley M LaughneyBrian W Pogue
Feb 2, 2011·Journal of Biomedical Optics·Bing YuNirmala Ramanujam
Feb 14, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jarich W SpliethoffTheo J M Ruers
Apr 15, 2014·Translational Oncology·Jarich W SpliethoffTheo J M Ruers
Jun 15, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jeffrey H J Tan, C David H Wrede
Mar 10, 2009·Current Opinion in Biotechnology·J Quincy BrownNirmala Ramanujam
Dec 19, 2006·Gynecologic Oncology·Ronald D AlvarezUNKNOWN Optical Detection Group
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Mar 6, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Michael S WeingartenKambiz Pourrezaei
Oct 16, 2007·International Journal of Cancer. Journal International Du Cancer·Claudia MujatIrene Georgakoudi
Mar 13, 2012·Lasers in Surgery and Medicine·Ronie GeorgeUrs Utzinger
Sep 11, 2010·International Journal of Cancer. Journal International Du Cancer·Scott B CantorMichele Follen
Jan 20, 2011·Lasers in Surgery and Medicine·Narasimhan RajaramJames W Tunnell

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