PMID: 2105922Feb 1, 1990Paper

Trimodality therapy (drug/hyperthermia/radiation) with BCNU or mitomycin C

International Journal of Radiation Oncology, Biology, Physics
T S HermanS A Holden

Abstract

To develop multimodality treatment combinations with high curative potential in advanced local disease, BCNU (N,N'-bis(2-chloroethyl)-N-nitro-sourea) and mitomycin C were tested with hyperthermia and radiation in the FSaIIC fibrosarcoma system. Growth delay experiments demonstrated that, while neither BCNU nor mitomycin C produced dose modification of the radiation response, and hyperthermia (43 degrees C, 30 min) produced only a moderate dose modification (1.4 +/- 0.2), the combination of BCNU plus hyperthermia resulted in a radiation dose modifying factor (DMF) of 1.9 +/- 0.3, and mitomycin C plus hyperthermia a dose modifying factor of 2.1 +/- 0.4. Tumor cell survival over a range of BCNU doses administered i.p. immediately before hyperthermia resulted in a dose modifying factor of 1.8 +/- 0.2 versus drug alone. With mitomycin C however, giving the drug immediately prior to heating produced a dose modifying factor due to hyperthermia of only 1.2 +/- 0.10. Hoechst 33342 diffusion was used to separate tumor cells into predominately oxic and hypoxic subpopulations. Administration of the single, double and trimodality therapies showed that BCNU was 3.1-fold more toxic to the oxic versus the hypoxic cells whereas mitomycin C was ...Continue Reading

References

Mar 1, 1988·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T S HermanC N Coleman
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H S Reinhold, B Endrich
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J L Wike-HooleyH S Reinhold
Mar 2, 1984·Science·B A Teicher, C M Rose

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Citations

Dec 1, 1989·International Journal of Radiation Oncology, Biology, Physics·T S HermanS M Fraser
Aug 1, 1995·Critical Reviews in Oncology/hematology·B A Teicher
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M R PfefferT S Herman
Jan 25, 2012·Journal of Oncology·Robert J GriffinMeenakshi Upreti
Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·J TanakaE Frei
Nov 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T S HermanS A Holden
Nov 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·B A TeicherT S Herman
Apr 22, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Antoine G van der Heijden, Mark W Dewhirst

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