PMID: 9174136May 1, 1997Paper

Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian

Tissue Antigens
M OtaH Inoko

Abstract

We recently identified a trinucleotide repeat polymorphism, (GCT)n, within the transmembrane (TM) segment of the human MHC class I MICA gene (MHC class I chain-related gene A). Five distinct alleles (A4, A5, A5.1, A6, A9) corresponding to 4, 5, 5 with one nucleotide insertion, 6 and 9 repetitions, respectively, have been detected in various HLA-homozygous B cell lines. Here we present allele frequencies for this trimeric short tandem repeat (STR) in 604 unrelated individuals collected from nine human populations (Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian) determined using the polymerase chain reaction (PCR) combined with fluorescent-based automated fragment detection technology. All alleles were present in each population, but allelic distributions varied from one population to another. No new alleles (such as A7 or A8) were identified. The evolutionary and structural significance of these data as well as the potential application to forensic medicine is discussed.

References

Oct 29, 1992·Nature·J WeissenbachM Lathrop
Aug 1, 1992·PCR Methods and Applications·K M SullivanJ M Robertson
Apr 1, 1972·Journal - Forensic Science Society·D A Jones
Jan 1, 1994·International Journal of Legal Medicine·J E LygoP Gill
Jan 1, 1994·International Journal of Legal Medicine·R A van OorschotS L Robinson
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Aug 1, 1993·PCR Methods and Applications·C P KimptonM Adams
Jul 1, 1993·Immunology Today·R D Campbell, J Trowsdale
Jan 1, 1996·Immunogenetics·S Bahram, T Spies
Jan 1, 1996·Immunogenetics·S BahramT Spies
Jan 1, 1996·Immunogenetics·N FodilS Bahram
Mar 5, 1996·Forensic Science International : Synergy·J F AndersenB H Parkin

❮ Previous
Next ❯

Citations

Jun 16, 2001·Arthritis and Rheumatism·A MartinezE G de la Concha
Oct 25, 2002·Diabetes/metabolism Research and Reviews·Norio AbiruKatsumi Eguch
Oct 19, 2004·Immunogenetics·Ainhoa Martín-PagolaJ Ramón Bilbao
Feb 3, 2009·Rheumatology International·Markéta FojtíkováMarie Cerná
Aug 8, 2009·International Journal of Colorectal Disease·Yi LiXiaolian Zhang
Feb 21, 2008·Wiener medizinische Wochenschrift·Marie Cerná
Mar 30, 2005·Current Diabetes Reports·Jennifer M Barker
Feb 10, 1999·International Journal of Cardiology·A KimuraF Numano
Aug 15, 2002·Human Immunology·Robert W M CollinsRobert W Vaughan
Jul 21, 2000·Tissue Antigens·A FoissacA Cambon-Thomsen
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K WienckeK M Boberg
Jul 15, 2009·Genetic Testing and Molecular Biomarkers·Shigehiro TamakiTadaaki Kirita
Mar 24, 2005·Thyroid : Official Journal of the American Thyroid Association·Manuela Dittmar, George J Kahaly
Mar 14, 2013·Journal of the National Cancer Institute·Dan ChenUlf Gyllensten
Nov 20, 1998·Tissue Antigens·A Foissac, A Cambon-Thomsen
May 13, 1999·Immunological Reviews·T ShiinaH Inoko
Apr 22, 2005·BMC Genomics·Elena UrcelayEmilio G de la Concha
May 19, 2010·Biomarkers in Medicine·Neeraj KumarNarinder Mehra
Jul 1, 2008·Expert Review of Clinical Immunology·Alberto FalorniGiovanni Gambelunghe
Apr 22, 2011·Annals of Human Biology·V DurmanováM Buc

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.