Trio gene is required for mouse learning ability

Brain Research
Wen ZongJiangang Gao

Abstract

Trio is a guanine nucleotide exchange factor with multiple guanine nucleotide exchange factor domains. Trio regulates cytoskeleton dynamics and actin remodeling and is involved in cell migration and axonal guidance in neuronal development. The null allele of the Trio gene led to embryonic lethality, and Trio null embryos displayed aberrant organization in several regions of the brain at E18.5, including hippocampus. Nestin-Trio-/- mice, in which the Trio gene was deleted specifically in the neuronal system by the Nestin-Cre system, displayed severe phenotypes, including low survival rate, ataxia and multiple developmental defects of the cerebellum. All Nestin-Trio-/- mice died before reaching adulthood, which hinders research on Trio gene function in adult mice. Thus, we generated EMX1-Trio-/- mice by crossing Trio-floxed mice with EMX1-Cre mice in which Cre is expressed in the brain cortex and hippocampus. EMX1-Trio-/- mice can survive to adulthood. Trio gene deletion results in smaller brains, an abnormal hippocampus and disordered granule cells in the dentate gyrus (DG) and cornu ammonis (CA). Behavior tests showed that Trio deletion interfered with the hippocampal-dependent spatial learning in the mice, suggesting that Trio...Continue Reading

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Citations

Jul 16, 2016·Journal of Medical Genetics·Reuben J PengellyDiana Baralle
Apr 3, 2019·International Journal of Molecular Sciences·Sadig Niftullayev, Nathalie Lamarche-Vane
Jun 4, 2019·The Journal of Biological Chemistry·Tao TaoMin-Sheng Zhu
Aug 16, 2019·Genes, Brain, and Behavior·Tingting ZhangJiangang Gao
Oct 20, 2019·The Journal of Biological Chemistry·Pengfei LiuAikseng Ooi
Jun 22, 2018·International Journal of Molecular Sciences·Valentina ZamboniGiorgio R Merlo
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Amy R DunnCatherine C Kaczorowski
Jan 27, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natàlia Pujol-GualdoMaría Soler Artigas
Mar 7, 2019·Cell Reports·Sara Marie KatranchaAnthony J Koleske
Mar 29, 2021·Journal of Molecular Neuroscience : MN·Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has

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