Abstract
Trio is a guanine nucleotide exchange factor with multiple guanine nucleotide exchange factor domains. Trio regulates cytoskeleton dynamics and actin remodeling and is involved in cell migration and axonal guidance in neuronal development. The null allele of the Trio gene led to embryonic lethality, and Trio null embryos displayed aberrant organization in several regions of the brain at E18.5, including hippocampus. Nestin-Trio-/- mice, in which the Trio gene was deleted specifically in the neuronal system by the Nestin-Cre system, displayed severe phenotypes, including low survival rate, ataxia and multiple developmental defects of the cerebellum. All Nestin-Trio-/- mice died before reaching adulthood, which hinders research on Trio gene function in adult mice. Thus, we generated EMX1-Trio-/- mice by crossing Trio-floxed mice with EMX1-Cre mice in which Cre is expressed in the brain cortex and hippocampus. EMX1-Trio-/- mice can survive to adulthood. Trio gene deletion results in smaller brains, an abnormal hippocampus and disordered granule cells in the dentate gyrus (DG) and cornu ammonis (CA). Behavior tests showed that Trio deletion interfered with the hippocampal-dependent spatial learning in the mice, suggesting that Trio...Continue Reading
References
Jan 10, 1991·Nature·H R BourneF McCormick
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·A DebantM Streuli
May 9, 1997·The Journal of Biological Chemistry·M R AlamB A Eipper
Sep 1, 1997·Human Molecular Genetics·V ColomerC A Ross
Apr 7, 1998·Cell·R StevenJ Culotti
Oct 28, 1998·Cell·X LiuS W Fesik
Jun 10, 2000·Cell·M Z Lin, M E Greenberg
Aug 19, 2000·The Journal of Biological Chemistry·Q G MedleyM Streuli
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P O'BrienM Streuli
Feb 28, 2002·Current Biology : CB·Soline EstrachAnne Debant
Oct 24, 2002·Brain Research. Molecular Brain Research·Yukio IshikawaManabu Negishi
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Jun 5, 2003·Brain Research. Molecular Brain Research·E M O'KaneB J Morris
Sep 6, 2005·Genes & Development·Robert StevenTony Pawson
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole C HuffJerry W Rudy
May 12, 2006·Biology of the Cell·Anne BlangyPhilippe Fort
Jul 19, 2006·Genesis : the Journal of Genetics and Development·Nicole C DuboisAndreas Trumpp
Jun 28, 2007·Reviews in the Neurosciences·Elodie Bruel-JungermanSerge Laroche
Apr 28, 2009·Molecular and Cellular Neurosciences·Ursula HaditschTheo D Palmer
May 28, 2009·BMB Reports·Eugene Lee, Hyeon Son
Jun 3, 2010·The Journal of Biological Chemistry·Ya-Jing PengMin-Sheng Zhu
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sergio AstigarragaJessica E Treisman
Jul 14, 2011·Genetics·Shuang HuRobert M Steven
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui YuZhe-Yu Chen
Oct 19, 2012·Cell Adhesion & Migration·Jos van Rijssel, Jaap D van Buul
Jul 10, 2014·ELife·Il Hwan KimRyohei Yasuda
Citations
Jul 16, 2016·Journal of Medical Genetics·Reuben J PengellyDiana Baralle
Oct 4, 2017·Human Molecular Genetics·Sara M KatranchaRichard E Mains
Apr 3, 2019·International Journal of Molecular Sciences·Sadig Niftullayev, Nathalie Lamarche-Vane
Jun 4, 2019·The Journal of Biological Chemistry·Tao TaoMin-Sheng Zhu
Aug 16, 2019·Genes, Brain, and Behavior·Tingting ZhangJiangang Gao
Oct 20, 2019·The Journal of Biological Chemistry·Pengfei LiuAikseng Ooi
Apr 5, 2020·Cells·Daji GuoLei Shi
Jun 22, 2018·International Journal of Molecular Sciences·Valentina ZamboniGiorgio R Merlo
Jul 7, 2020·Frontiers in Genetics·Thiago CorrêaMariluce Riegel
Oct 28, 2019·Brain Sciences·Nicoletta NuzzielloMaria Liguori
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Amy R DunnCatherine C Kaczorowski
Jan 27, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Natàlia Pujol-GualdoMaría Soler Artigas
Mar 7, 2019·Cell Reports·Sara Marie KatranchaAnthony J Koleske
Mar 29, 2021·Journal of Molecular Neuroscience : MN·Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has
May 9, 2021·Molecular Psychiatry·Xiaoxuan SunJun Li
May 21, 2021·Neurogenetics·K KlothF Kortüm
Jul 24, 2021·Biology of Reproduction·Yi-Meng XiongHe-Feng Huang
Feb 29, 2020·American Journal of Human Genetics·Sónia BarbosaDiana Baralle
Dec 17, 2021·Neuroscience Bulletin·Chengwen WeiJun Li