TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a

Biochemical and Biophysical Research Communications
Wenhui ZhaoXiaohui Zhao

Abstract

Thyroid hormone receptor-interacting protein 6 (TRIP6), a member of LIM family, acts as an adaptor protein and is overexpressed in several tumor types. However, the clinical significance and biological role of TRIP6 in HCC remains unknown. In our study, we found that TRIP6 was markedly overexpressed in HCC cells and clinical specimens compared with normal hepatocytes and adjacent non-tumor tissues. Immunohistochemical and statistical analysis showed that the expression of TRIP6 significantly correlated with HCC patients' clinical stage and poor survival. Moreover, we demonstrated that overexpressing TRIP6 significantly enhanced, whereas silencing endogenous TRIP6 inhibited, the proliferation and the anchorage-independent growth ability of HCC cells. In addition, overexpression of TRIP6 accelerated, while inhibition of TRIP6 retarded, G1-S phase transition in HCC cells. We further found that overexpression of TRIP6 increased the activation of AKT and suppressed the transactivity of FOXO3a. Meanwhile, overexpression of TRIP6 leaded to the decreased expression of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 and increased expression of the cell cycle regulator cyclin D1. While silencing TRIP6 triggered the opposite effect...Continue Reading

Citations

Feb 23, 2020·Cancer Cell International·Xiaohui ZhaoYan Zhang
Aug 28, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Sen HanZhihong Yang
Aug 7, 2021·Journal of Personalized Medicine·Chien-Jung HuangYu-Chao Wang
Aug 25, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y Taank, N Agnihotri

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