Tripartilactam, a cyclobutane-bearing tricyclic lactam from a Streptomyces sp. in a dung beetle's brood ball

Organic Letters
Seon-Hui ParkDong-Chan Oh

Abstract

Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na(+)/K(+) ATPase inhibitor (IC(50) = 16.6 μg/mL).

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Aug 30, 2011·Bioorganic & Medicinal Chemistry Letters·Seong-Hwan KimDong-Chan Oh

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Citations

Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Valery M Dembitsky
Aug 25, 2016·Applied Microbiology and Biotechnology·Khomsan SupongPattama Pittayakhajonwut
May 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patrick HillChristopher N Boddy
Jul 27, 2017·Chemical Society Reviews·Ethan B Van ArnamJon Clardy
Mar 16, 2016·Beilstein Journal of Organic Chemistry·Christine BeemelmannsMichael Poulsen
Sep 22, 2020·Chemistry : a European Journal·Wanderson C de SouzaMarcio W Paixão
Jan 2, 2021·Marine Drugs·Pei WangWeiming Zhu
Jan 4, 2020·Journal of Natural Products·Sunghoon HwangDong-Chan Oh
Dec 23, 2016·Journal of Natural Products·Hee Rae KangKi Hyun Kim
Feb 20, 2014·The Journal of Organic Chemistry·Will R Gutekunst, Phil S Baran
Feb 20, 2020·Journal of Natural Products·Yern-Hyerk ShinDong-Chan Oh

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