Triphasic oral contraception: metabolic effects in normal women and those with previous gestational diabetes

American Journal of Obstetrics and Gynecology
S O SkoubyM S Christensen

Abstract

The effect of a low-dose triphasic oral contraceptive (ethinyl estradiol and levonorgestrel) on glucose tolerance, plasma insulin and glucagon responses to glucose, fasting plasma cortisol, triglycerides, free fatty acids, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very--low-density lipoprotein cholesterol was investigated in 16 women with previous gestational diabetes and in 19 normal women. Investigations were performed prior to the hormonal intake and after treatment for 2 and 6 months. Before treatment, the women with previous gestational diabetes had significantly elevated fasting glucose (p less than 0.05) and impaired glucose tolerance (p less than 0.05) when compared to those of the healthy control subjects. The glucose, insulin, and glucagon responses to oral glucose remained unchanged during the treatment period. Plasma cortisol increased in both groups (p less than 0.05) whereas plasma triglycerides increased in the control subjects only (p less than 0.05). Plasma free fatty acids, lipoproteins, and high-density lipoprotein cholesterol/total cholesterol ratio remained unchanged in both groups. The results suggest that a low-dose triphasic oral contraceptive (ethi...Continue Reading

References

Jun 1, 1975·Journal of Steroid Biochemistry·R K Kalkhoff
Jan 1, 1981·Pharmacology & Therapeutics·B L Furman
Jan 1, 1982·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·M H Briggs, M Briggs

Citations

Feb 7, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Pierre Gourdy
Mar 1, 2000·Clinical Obstetrics and Gynecology·Siri L Kjos
Oct 1, 2009·Diabetes, Obesity & Metabolism·Catherine Kim
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·V Kerlan
Oct 1, 1986·American Journal of Obstetrics and Gynecology·S O SkoubyC Kühl
May 1, 1988·Canadian Family Physician Médecin De Famille Canadien·A V Pavilanis
May 1, 1989·American Journal of Obstetrics and Gynecology·R A Chez
Nov 1, 1989·American Journal of Obstetrics and Gynecology·W A BowesT G Bright
Jul 1, 1990·American Journal of Obstetrics and Gynecology·I F GodslandV Wynn
Jul 1, 1990·American Journal of Obstetrics and Gynecology·D SimonL Papoz
Dec 18, 2010·Diabetes & Metabolism·V Kerlan
Jun 19, 2007·Obstetrics and Gynecology Clinics of North America·Siri L Kjos
Jun 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·S O SkoubyK R Petersen
Sep 25, 2014·The Linacre Quarterly·Manuel E Cortés, Andrea A Alfaro
Aug 11, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Johan Verhaeghe
Mar 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E EschwégeL Papoz
Apr 1, 1986·Journal of Obstetrics and Gynaecology·S O Skouby
Nov 7, 2013·The Journal of Clinical Endocrinology and Metabolism·Ian BlumerYariv Yogev
Mar 23, 1989·The New England Journal of Medicine·D R Mishell
Oct 23, 2002·Journal of Applied Physiology·Sang-Hoon SuhGeorge A Brooks

Related Concepts

Blood Glucose
Combined Oral Contraceptives
Drug Administration Schedule
Ethinyl Estradiol, (9 beta,17 alpha)-Isomer
Glucagon
Intravenous Glucose Tolerance Test
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Insulin B Chain
Lipids
Postinor

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