Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells

Bioorganic & Medicinal Chemistry Letters
Rahul Palchaudhuri, Paul J Hergenrother

Abstract

Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.

References

Jun 6, 2003·Oncogene·María S Soengas, Scott W Lowe
May 5, 2005·Current Treatment Options in Oncology·Ehab Atallah, Lawrence Flaherty
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ulrich KeilholzAlexander M M Eggermont

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis