PMID: 9425734Jan 13, 1998Paper

Triple check for antigen specificity of B cells during germinal centre reactions

Immunology Today
E LindhoutC de Groot

Abstract

Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells.

References

Dec 1, 1992·European Journal of Immunology·M A Valentine, K A Licciardi
May 1, 1991·European Journal of Immunology·M MangeneyJ Wiels
Dec 21, 1989·Nature·Y J LiuI C MacLennan
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H De LoofJ M Ruysschaert
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Nov 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Krenács, M Rosendaal
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Apr 1, 1993·European Journal of Immunology·J Y BonnefoyJ Gordon
Apr 1, 1996·Immunological Reviews·D GrayP Dullforce
Sep 1, 1996·The Journal of Experimental Medicine·B ZhengG Kelsoe

❮ Previous
Next ❯

Citations

May 16, 2001·Arthritis and Rheumatism·R A Carter, I P Wicks
Jul 13, 2002·Arthritis and Rheumatism·Weiqing HuangAnne Davidson
Feb 10, 1999·Medical Oncology·L M Osorio, M Aguilar-Santelises
Mar 28, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Feng WangGuanxin Shen
Jun 27, 2009·Pathology Oncology Research : POR·Ferenc SiposBéla Molnár
Aug 7, 2002·Seminars in Immunology·Kirsten van Nierop, Cornelis de Groot
Dec 12, 2001·Trends in Immunology·M van EijkC de Groot
Aug 14, 1999·Immunology·J C EdwardsV M Abrahams
Mar 2, 1999·The Journal of Experimental Medicine·P A Koni, R A Flavell
Nov 12, 2003·The Journal of Experimental Medicine·Marcel SpaargarenSteven T Pals
Oct 17, 2007·The Journal of Experimental Medicine·Richard J BendeCarel J M van Noesel
Jun 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Carmen SegundoJosé A Brieva
Feb 27, 2001·The American Journal of Surgical Pathology·L de LevalN L Harris
Dec 3, 1999·Immunological Reviews·P BrandtzaegT Yamanaka
Apr 7, 2010·Annual Review of Physical Chemistry·Arup K Chakraborty, Andrej Kosmrlj
Jul 6, 2000·The Journal of Clinical Investigation·M MiharaA Davidson
Nov 25, 2000·Clinical and Experimental Immunology·H IllgesI Melchers
Jan 23, 2014·Advanced Drug Delivery Reviews·Christoph Giese, Uwe Marx
Apr 23, 2002·Traffic·Willem StoorvogelGraça Raposo
Sep 8, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kirsten van NieropCornelis de Groot
Jul 29, 2005·Immunological Reviews·Per Brandtzaeg, Finn-Eirik Johansen
Oct 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E Di CarloC Sorrentino
Apr 6, 2004·Rheumatic Diseases Clinics of North America·William P Arend, Cem Gabay
Mar 28, 2012·International Reviews of Immunology·Helena Block, Alexander Zarbock
Nov 21, 1998·Cell Adhesion and Communication·S T PalsR M Keehnen
May 11, 2010·Immunological Investigations·Per Brandtzaeg
Sep 18, 2012·Acta Physiologica Hungarica·M ConstantinovitsGy Műzes
Jun 9, 2001·Journal of Theoretical Biology·M Meyer-HermannM Or-Guil
Apr 27, 2010·Journal of Biotechnology·Christoph GieseUwe Marx
Aug 24, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jean-Jacques GovalLaurence de Leval
Sep 1, 2000·International Immunology·M BrandesB Moser
Nov 28, 2001·Hematology·N L HarrisW C Chan
Nov 20, 2014·Brain Tumor Research and Treatment·Juneyoung Heo, Sung Jin Cho
Jan 9, 2015·The Journal of Craniofacial Surgery·Vasily A CherekaevTatiana V Tsukanova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.