PMID: 8595515Jan 1, 1995Paper

Triple combinations: present and future

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
J M Lange

Abstract

Three or more therapeutic agents have commonly been used to treat chronic infections and many malignant diseases. It is clear that monotherapy treatment of HIV infection, although effective in the short term, is not a viable long-term management option because of incomplete suppression of viral replication and the subsequent development of viral resistance. It is therefore generally accepted that multidrug combination therapy represents the most promising strategy for HIV management. The rationale for this approach is based on an understanding of viral pathogenesis and preliminary results from in vitro studies. It is anticipated that combination therapy will achieve greater reductions in viral load, leading to reduced rates of viral replication and diversification, which, in turn, will result in the delayed emergence of drug-resistant and cytopathic variants. This will probably result in the prevention of both immune system destruction and subsequent disease progression. Preliminary in vitro studies have provided evidence that double combinations are more effective than monotherapy. In vivo results from clinical trials comparing double combinations with monotherapy, however, have not been as impressive as expected, and show tha...Continue Reading

Citations

Jul 1, 1997·Memórias do Instituto Oswaldo Cruz·M C Portela, K N Simpson
May 20, 1997·AIDS Research and Human Retroviruses·C C TsaiP J Dailey
Apr 10, 2009·The Oncologist·Nathan A Pennell, Thomas J Lynch
Aug 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M J PazzaniJ Tilles

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