Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary 18 F-NaF PET

European Journal of Nuclear Medicine and Molecular Imaging
Martin L LassenPiotr J Slomka

Abstract

To improve the test-retest reproducibility of coronary plaque 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake measurements. We recruited 20 patients with coronary artery disease who underwent repeated hybrid PET/CT angiography (CTA) imaging within 3 weeks. All patients had 30-min PET acquisition and CTA during a single imaging session. Five PET image-sets with progressive motion correction were reconstructed: (i) a static dataset (no-MC), (ii) end-diastolic PET (standard), (iii) cardiac motion corrected (MC), (iv) combined cardiac and gross patient motion corrected (2 × MC) and, (v) cardiorespiratory and gross patient motion corrected (3 × MC). In addition to motion correction, all datasets were corrected for variations in the background activities which are introduced by variations in the injection-to-scan delays (background blood pool clearance correction, BC). Test-retest reproducibility of PET target-to-background ratio (TBR) was assessed by Bland-Altman analysis and coefficient of reproducibility. A total of 47 unique coronary lesions were identified on CTA. Motion correction in combination with BC improved the PET TBR test-retest reproducibility for all lesions (coefficient of reproducibility: stan...Continue Reading

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Citations

May 8, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Evangelos Tzolos, Marc R Dweck
Dec 25, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jamie W Bellinge, Carl J Schultz
Jul 4, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Evangelos TzolosPiotr Slomka
Nov 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Poul F Høilund-CarlsenOke Gerke
Jun 13, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Evangelos TzolosPiotr J Slomka
Oct 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr J SlomkaErnest V Garcia
Nov 11, 2020·Scientific Reports·R KlénJ Knuuti
Nov 12, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexander J Fletcher, Marc R Dweck
Oct 24, 2020·Diagnostics·Poul F Høilund-CarlsenOke Gerke
Dec 11, 2020·Circulation. Cardiovascular Imaging·Panithaya Chareonthaitawee, Fabien Hyafil
Jan 22, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Johannes MayerChristoph Kolbitsch
Jan 22, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexander J FletcherMarc R Dweck
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Oct 18, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Piotr J SlomkaErnest V Garcia
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Jun 20, 2020·Journal of the American College of Cardiology·Zahi A Fayad, Philip M Robson
Aug 28, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jacek Kwiecinski, Marc R Dweck
Sep 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jussi SchultzJarmo Teuho

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