Triple-Layer Vascular Grafts Fabricated by Combined E-Jet 3D Printing and Electrospinning

Annals of Biomedical Engineering
Ruiying HuangZhikai Tan

Abstract

Small-diameter tissue-engineered vascular grafts are urgently needed for clinic arterial substitute. To simulate the structures and functions of natural blood vessels, we designed a novel triple-layer poly(ε-caprolactone) (PCL) fibrous vascular graft by combining E-jet 3D printing and electrospinning techniques. The resultant vascular graft consisted of an interior layer comprising 3D-printed highly aligned strong fibers, a middle layer made by electrospun densely fibers, and an exterior structure composed of mixed fibers fabricated by co-electrospraying. The biocompatible triple-layer graft was used for in vivo implantation, and results demonstrated that the longitudinally-aligned fibers within the lumen of the graft could enhance the proliferation and migration of endothelial cells, while maintained good mechanical properties. The exterior layer provided a pathway that encouraged cells to migrate into the scaffold after implantation. This experimental graft overcame the limitations of conventionally electrospun vascular grafts of inadequate porosity and lowly cell penetration. The unique structure of the triple-layer vascular graft promoted cell growth and infiltration in vivo, thus provided an encouraging substitute for in s...Continue Reading

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Citations

Feb 20, 2019·Journal of Biomechanical Engineering·Ehab Akram TamimiJonathan Vande Geest
Oct 28, 2019·Journal of Biomedical Materials Research. Part a·Haoyong YuanZhongshi Wu
Feb 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dongfang WangLih-Sheng Turng
Jul 25, 2019·Frontiers in Bioengineering and Biotechnology·Dilara Goksu TamayVasif Hasirci
Dec 18, 2020·Journal of Biomaterials Science. Polymer Edition·Qingxi HuMurugan Ramalingam
Nov 1, 2020·Biomaterials·Wissam FarhatAlexandra Fuchs
Feb 16, 2021·Frontiers in Cardiovascular Medicine·Bruna B J LealPatricia Pranke
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Jan 21, 2020·ACS Applied Materials & Interfaces·Meiling WenXiaoyan Yuan
Nov 7, 2020·ACS Applied Materials & Interfaces·Seongsu EomDong Sung Kim

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