Triple negative breast cancer: an Indian perspective

Breast Cancer : Targets and Therapy
Murtaza AkhtarMurtuza Rangwala

Abstract

Breast cancer is the most common female cancer in the world. Triple negative breast cancer (TNBC) is a recently identified biological variant with aggressive tumor behavior and poor prognosis. Data of hormonal status from the Indian population is scarce due to financial constraints in performing immunohistochemistry evaluation. The present study aims to prospectively analyze receptor status of all breast cancer patients and identify TNBC and compare their clinical profile and short term survival with other non-TNBC group. All cytologically and histopathologically confirmed cases of carcinoma breast were prospectively enrolled. In a longitudinal study at tertiary care hospital in central India based on the hormonal status, they were further divided into TNBC and other groups. Comparison of risk factors, clinical profile and short-term survival was carried out. A total 85 patients were enrolled and of them 37 (43.7%) were TNBC. On comparing risk factors ie, age, age at menarche, total reproductive age, age at first child birth, and menopausal status - no statistical significance was observed between the TNBC and non-TNBC groups. But on comparison of clinical profile TNBC tumors were significantly large with majority of patients p...Continue Reading

Citations

Aug 10, 2020·Indian Journal of Pathology & Microbiology·Harshima D WijesingheMenaka D S Lokuhetty
Apr 8, 2020·Journal of Oncology·Atika DograDinesh Chandra Doval
Oct 12, 2018·Indian Journal of Pathology & Microbiology·Amir Hossein JafarianNema Mohamadian Roshan
Jan 2, 2021·Chemistry and Physics of Lipids·Sai Kiran S S PindiproluPavan Kumar Chintamaneni
Aug 22, 2020·Life Sciences·Parisa LotfinejadBehzad Baradaran

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BETA
biopsy
X-ray

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