Triple-negative breast cancer molecular subtyping and treatment progress

Breast Cancer Research : BCR
Li YinShi-Cang Yu

Abstract

Triple-negative breast cancer (TNBC), a specific subtype of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER-2), has clinical features that include high invasiveness, high metastatic potential, proneness to relapse, and poor prognosis. Because TNBC tumors lack ER, PR, and HER2 expression, they are not sensitive to endocrine therapy or HER2 treatment, and standardized TNBC treatment regimens are still lacking. Therefore, development of new TNBC treatment strategies has become an urgent clinical need. By summarizing existing treatment regimens, therapeutic drugs, and their efficacy for different TNBC subtypes and reviewing some new preclinical studies and targeted treatment regimens for TNBC, this paper aims to provide new ideas for TNBC treatment.

References

Jul 11, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R B WeissB Leyland-Jones
Mar 24, 2000·Essays in Biochemistry·E E Trimmer, J M Essigmann
Aug 30, 2000·Nature·C M PerouD Botstein
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I Craig HendersonLarry Norton
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacques BonneterreIsabelle Chapelle-Marcillac
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lucio Tentori, Grazia Graziani
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark N LevineUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Sep 17, 2005·Biochemical and Biophysical Research Communications·Zhaoyi WangThomas F Deuel
Nov 1, 2005·The Lancet Oncology·Maureen TrudeauShailendra Verma
Dec 13, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chad A LivasyCharles M Perou
May 3, 2006·Cancer Research·François BertucciDaniel Birnbaum
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhaoyi WangThomas F Deuel
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca DentSteven A Narod
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael J HayesCelina G Kleer
Aug 5, 2008·Cancer Research·Katherine Stemke-HaleBryan T Hennessy
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana M Gonzalez-AnguloBryan T Hennessy
Nov 11, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O GluzN Harbeck
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joshua A BauerJennifer A Pietenpol
Jun 29, 2010·Current Cancer Drug Targets·H MaoX Qu
Jan 15, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana M Gonzalez-AnguloFunda Meric-Bernstam
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Jul 5, 2011·Journal of Women's Health·Lisa M HinesMeenakshi Singh
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Apr 4, 2012·Biochemical Pharmacology·Mike De VosFrançoise Dantzer
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa A CareyEric P Winer
Apr 30, 2013·Journal of Leukocyte Biology·Andrew M Intlekofer, Craig B Thompson
May 2, 2013·Therapeutic Advances in Medical Oncology·John Stagg, Bertrand Allard
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Aug 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroko MasudaNaoto T Ueno
Aug 24, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ayca GucalpUNKNOWN Translational Breast Cancer Research Consortium (TBCRC 011)
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Oct 12, 2013·The Journal of Pathology·Brian D Lehmann, Jennifer A Pietenpol
May 16, 2014·Cancer Research·Ira Pastan, Raffit Hassan
May 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jian ZhangZhimin Shao
Jul 22, 2014·Cancer·Vandana G AbramsonJennifer A Pietenpol
Sep 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew D BursteinPowel H Brown
Nov 14, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zoran GatalicaOmid Hamid

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Citations

Dec 3, 2020·Molecular Carcinogenesis·Noura N Alraouji, Abdelilah Aboussekhra
Dec 20, 2020·Clinical Genetics·Agata SzymiczekMohammad R Akbari
Jan 21, 2021·Non-coding RNA·Debina Sarkar, Sarah D Diermeier
Feb 2, 2021·Biochemical and Biophysical Research Communications·Qing WangChunmeng Shi
Jan 16, 2021·Medicina·Sylvia Annabel DassVenugopal Balakrishnan
Feb 25, 2021·Breast Cancer Research and Treatment·Muthukrishnan ChandrikaBoon Huat Bay
Feb 27, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Anup PaulArmando J L Pombeiro
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Josline Neetha D'SouzaD J Manasa
Apr 5, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Christine SongSeungBaek Lee
Apr 13, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ragini YeeravalliAmitava Das
Apr 18, 2021·Stem Cell Research & Therapy·Kai Song, Maryam Farzaneh
Apr 30, 2021·Frontiers in Immunology·Shuvasree SenGuptaCarole A Parent
May 1, 2021·International Journal of Molecular Sciences·Barbara Kutryb-ZajacRyszard T Smolenski
Jun 3, 2021·International Journal of Molecular Sciences·Thu-Huyen PhamDo-Young Yoon
Jun 3, 2021·Antioxidants·Katerina SpyridopoulouKaterina Chlichlia
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sebastian SimuDan Navolan
May 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hui JiaJincai Lu
Jun 21, 2021·Seminars in Cancer Biology·Zhan HuaJianjun Zhou
Jul 3, 2021·International Journal of Molecular Sciences·Shizhen Zhao, Honggang Wang
Jul 3, 2021·Journal of Personalized Medicine·Fatemah BahmanKhaled Greish
Jun 15, 2021·Frontiers in Molecular Biosciences·Elena AlbertsAnita Grigoriadis
Jul 24, 2021·Journal of Experimental & Clinical Cancer Research : CR·Lisa AgnelloLaura Cerchia
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernanda MalhãoAlice Abreu Ramos
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Long SunCheng-Zhu Wu
Jul 2, 2021·International Journal of Pharmaceutics·Rahul ChadarPrashant Kesharwani
Aug 8, 2021·International Journal of Molecular Sciences·Amanda ChantziouPanayiotis A Theodoropoulos

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Methods Mentioned

BETA
chip
RNA-seq
xenografts

Clinical Trials Mentioned

NCT00601159
NCT00232505
NCT01623349
NCT01927419

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