Abstract
To evaluate the prognostic value of determining estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) expression in node-positive breast cancer patients treated with mastectomy. The records of 835 node-positive breast cancer patients who had undergone mastectomy between January 2000 and December 2004 were analyzed retrospectively. Of these, 764 patients (91.5%) received chemotherapy; 68 of 398 patients (20.9%) with T1-2N1 disease and 352 of 437 patients (80.5%) with T3-4 or N2-3 disease received postoperative radiotherapy. Patients were classified into four subgroups according to hormone receptor (Rec+ or Rec-) and HER2 expression profiles: Rec-/HER2- (triple negative; n = 141), Rec-/HER2+ (n = 99), Rec+/HER2+ (n = 157), and Rec+/HER2- (n = 438). The endpoints were the duration of locoregional recurrence-free survival, distant metastasis-free survival, disease-free survival, and overall survival. Patients with triple-negative, Rec-/HER2+, and Rec+/HER2+ expression profiles had a significantly lower 5-year locoregional recurrence-free survival than those with Rec+/HER2- profiles (86.5% vs. 93.6%, p = 0.002). Compared with those with Rec+/HER2+ and Rec+/HER2- profiles, patients with Rec-/H...Continue Reading
References
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Sep 29, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alphonse TaghianNorman Wolmark
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Feb 2, 2006·CA: a Cancer Journal for Clinicians·S Eva Singletary, James L Connolly
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Aug 30, 2006·Human Pathology·Mi-Jung KimGyungyub Gong
Nov 23, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce G HafftyDeborah Toppmeyer
Feb 20, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marie OvergaardJens Overgaard
Mar 28, 2007·Cancer·Katrina R BauerVincent Caggiano
Jul 26, 2007·BMC Cancer·Marc TischkowitzWilliam D Foulkes
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca DentSteven A Narod
Nov 6, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·A A LuckI O Ellis
Nov 30, 2007·Human Pathology·Hui LiuFanqing Meng
Feb 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marianne KyndiUNKNOWN Danish Breast Cancer Cooperative Group
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maggie C U CheangTorsten O Nielsen
Apr 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul L NguyenJay R Harris
Jun 11, 2008·Breast Cancer Research and Treatment·Rebecca DentSteven A Narod
Jul 1, 2008·The Oncologist·Issa J DahabrehSamuel Murray
Oct 7, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mia VoordeckersGuy Storme
Oct 9, 2009·The Breast : Official Journal of the European Society of Mastology·Fredrika KillanderPer Malmström
Citations
Oct 4, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W Eiermann, K A Vallis
Jan 22, 2013·The Oncologist·Xingxing ChenYan Feng
Feb 4, 2014·Annals of Surgical Oncology·Tracy-Ann MooMahmoud El-Tamer
Apr 12, 2013·Cancer·Xingxing ChenYan Feng
Oct 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Michael I KoukourakisAlexandra Giatromanolaki
Jul 28, 2012·The Breast : Official Journal of the European Society of Mastology·San-Gang WuXun-Xing Guan
Jan 24, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C BourgierD Azria
Apr 5, 2012·Journal of Surgical Oncology·Catherine C ParkerQuyen D Chu
Jan 30, 2014·Cancer Cell International·Hai CuiXiong-Hu Shen
May 11, 2012·International Journal of Radiation Oncology, Biology, Physics·Jessica SelzRomuald Le Scodan
Mar 20, 2015·Cell Death & Disease·M K FarrugiaJ M Ruppert
May 29, 2015·PloS One·Wenjie ZhuBinghe Xu
Jul 8, 2016·SpringerPlus·Shreya PrasadTithi Biswas
Sep 24, 2016·Practical Radiation Oncology·Abram RechtStephen B Edge
Sep 21, 2016·Annals of Surgical Oncology·Abram RechtStephen B Edge
Oct 27, 2016·Annals of Surgical Oncology·Julia C RadosaTari A King
Sep 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Abram RechtStephen B Edge
Jan 5, 2019·PloS One·Seied Asadollah MousaviSahar Tavakoli
Sep 21, 2017·Medicine·Minghai ShaoXinchen Sun
Feb 13, 2020·Cancer Medicine·Jiangfeng WangXiaomao Guo
Aug 14, 2018·Oncotarget·Tomás MerinoCésar Sánchez
Dec 8, 2011·Breast Cancer Research and Treatment·Aoife J LoweryKarl J Sweeney
Sep 6, 2020·Journal of Racial and Ethnic Health Disparities·Hua-Ren CherngElizabeth Nichols
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Poom AdisakwattanaOnrapak Reamtong
Apr 9, 2019·BJS Open·S S K TangG P H Gui
Feb 13, 2021·Frontiers in Oncology·Guang-Yi SunYe-Xiong Li
Sep 27, 2013·Molecular Pharmaceutics·Bryan HoangChristine Allen