Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis: Implications for Very Early Identification of At-Risk Individuals

Arthritis & Rheumatology
M K VerheulL A Trouw

Abstract

In rheumatoid arthritis (RA), anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these autoantibodies are mainly found in RA, their specificity is not optimal. It is therefore difficult to identify RA patients, especially in very early disease, based on the presence of ACPAs and RF alone. In addition, anti-carbamylated protein (anti-CarP) antibodies have diagnostic and prognostic value, since their presence is associated with joint damage in RA patients and also associated with the future development of RA in patients with arthralgia. Therefore, the aim of the present study was to investigate the value of combined antibody testing in relation to prediction and diagnosis of (early) RA. A literature search resulted in identification of 12 relevant studies, consisting of RA patients, pre-RA individuals, disease controls, healthy first-degree relatives of RA patients, and healthy control subjects, in which data on RF, ACPAs, and anti-CarP antibody status were available. Using these data, random effects meta-analyses were carried out for several antibody combinations. The individual antibodies were highly prevalent in patients with RA (34-80%) compared to the ...Continue Reading

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Citations

Feb 12, 2019·Nature Reviews. Rheumatology·Jose U ScherChristopher Ritchlin
Sep 29, 2019·Journal of Internal Medicine·S Rantapää Dahlqvist, F Andrade
Dec 18, 2019·Immunological Reviews·Mikhail VolkovDiane van der Woude
Aug 27, 2019·Arthritis & Rheumatology·Ken C LoKatherine A Siminovitch
Jun 6, 2020·Arthritis & Rheumatology·Peter SahlströmCaroline Grönwall
Jan 27, 2019·International Journal of Rheumatic Diseases·Jinxia Zhao, Zhan-Guo Li
May 26, 2020·Arthritis Research & Therapy·Yanpeng LiRikard Holmdahl
Jan 30, 2019·Frontiers in Immunology·Shawn A Mahmud, Bryce A Binstadt
Dec 7, 2018·Frontiers in Immunology·Marvin J FritzlerMichael Mahler
Nov 8, 2020·Scientific Reports·Lorena Rodriguez-MartínezAntonio Gonzalez
Aug 10, 2020·Arthritis & Rheumatology·Liam J O'NeilHani S El-Gabalawy
Jul 1, 2020·Arthritis & Rheumatology·Kevin D Deane, V Michael Holers
Dec 22, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yuan ZhangLiyan Cui
Feb 26, 2021·Therapeutic Advances in Musculoskeletal Disease·Bogdan KolarzMaria Majdan
Mar 23, 2021·Autoimmunity Reviews·Nora PetrovskáMária Filková
Mar 31, 2021·Expert Review of Proteomics·Anne C Bay-JensenClaus H Nielsen
Sep 24, 2020·Journal of Proteome Research·Rui VitorinoJennifer E Van Eyk
Sep 22, 2021·Virology Journal·Abdulrahim R HakamiAli Essa Asiry
Oct 1, 2021·International Journal of Pharmaceutics·Parastou RahimizadehSung In Lim
Jan 8, 2022·The Journal of Applied Laboratory Medicine·Janet MartinWaliul I Khan

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