Triple quadrupole tandem mass spectrometry: A real alternative to high resolution magnetic sector instrument for the analysis of polychlorinated dibenzo-p-dioxins, furans and dioxin-like polychlorinated biphenyls

Analytica Chimica Acta
Ángel García-BermejoBelén Gómara

Abstract

This paper reports on the optimisation, characterisation, validation and applicability of gas chromatography coupled to triple quadrupole mass spectrometry in its tandem operation mode (GC-QqQ(MS/MS) for the quantification of polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs, dioxins) and dioxin-like polychlorinated biphenyls (DL-PCBs) in environmental and food matrices. MS/MS parameters were selected to achieve the high sensitivity and selectivity required for the analysis of this type of compounds and samples. Good repeatability for areas (RSD = 1-10%, for PCDD/Fs and DL-PCBs) and for ion transition ratios (RSD = 0.3-10%, for PCDD/Fs, and 0.2-15%, for DL-PCBs) and low instrumental limits of detection, 0.07-0.75 pg μL(-1) (for dioxins) and 0.05-0.63 pg μL(-1) (for DL-PCBs), were obtained. A comparative study of the congener specific determination using both GC-QqQ(MS/MS) and gas chromatography-high resolution mass spectrometry (GC-HRMS) was also performed by analysing several fortified samples and certified reference materials (CRMs) with low (feed and foodstuffs), median (sewage sludge) and high (fly ash) toxic equivalency (TEQ) concentration levels, i.e. 0.60, 1.83, 72.9 and 3609 pg WHO-TEQ(PCDD/Fs) g(-1). The agreement ...Continue Reading

References

Jul 11, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Van den BergRichard E Peterson
Apr 10, 2008·Journal of Separation Science·Diego García-RodríguezRosa Antonia Lorenzo-Ferreira
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Jul 17, 2014·Food Additives & Contaminants. Part B, Surveillance·D Zacs, V Bartkevics

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Citations

Apr 11, 2017·Journal of Agricultural and Food Chemistry·Ángel García-BermejoBelén Gómara
Nov 2, 2019·International Journal of Environmental Research and Public Health·Wenjing GuoHuixiao Hong
Nov 14, 2019·International Journal of Environmental Research and Public Health·Wenjing GuoHuixiao Hong
Jun 10, 2020·Journal of Agricultural and Food Chemistry·Guodong CaoZongwei Cai

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