Triple stimuli-responsive keratin nanoparticles as carriers for drug and potential nitric oxide release

Materials Science & Engineering. C, Materials for Biological Applications
Yanmei LiJiang Yuan

Abstract

Development of pH/GSH/enzyme triple stimuli-responsive drug delivery system is promising for tumor therapy due to more acidic, higher glutathione (GSH) level, and overexpressed trypsin under tumor microenvironment. Herein, keratin/doxorubicin (DOX) complex nanoparticles (KDNPs) were for the first time prepared using a drug-induced ionic gelation technique without cross-linker, organic solvent and surfactant. The resultant KDNPs had high drug loading efficacy and performed considerably stable in aqueous solution. Drug delivery curves showed that KDNPs exhibited triple-responsive characters (pH, GSH, and enzyme). Under tumor microenvironments (acid and high GSH level), KDNPs performed surface charge conversion of negative-to-positive and enhanced permeation retention effect (EPR), which both benefited the drug accumulation. Furthermore, the overexpressed trypsin would cleave the peptide bonds within KDNPs and enhance the DOX release. KDNPs were demonstrated to be internalized by A549 cells through endocytosis by cellular uptake assay. Cytotoxicity assay indicated that KDNPs could inhibit the proliferation of tumor cells efficiently. In vivo cytotoxicity and hemolysis tests suggested that KDNPs exhibited excellent biocompatibility...Continue Reading

Citations

Jul 24, 2018·Journal of Biomaterials Science. Polymer Edition·Xiuzhen WanJian Shen
Sep 6, 2018·Journal of Biomaterials Science. Polymer Edition·Xuelian ZhiJiantao Lin
Jun 27, 2020·Journal of Biomaterials Science. Polymer Edition·Lijuan WangJiang Yuan
Jul 31, 2020·Journal of Biomaterials Science. Polymer Edition·Xiao HanJian Shen
Aug 25, 2020·Advanced Therapeutics·Noah PacificiJamal S Lewis
Sep 2, 2020·Advanced Drug Delivery Reviews·Anastasia VarankoAshutosh Chilkoti
Jan 5, 2021·Frontiers in Molecular Biosciences·Reju George ThomasYong Yeon Jeong
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Greta AvanciniFrancesca Moret
Mar 20, 2021·Journal of Biomaterials Science. Polymer Edition·Jinsong DuJian Shen
Jul 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiao HanJian Shen
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Huifang Zhang, Peng Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.