Triple therapy for neovascular age-related macular degeneration (verteporfin photodynamic therapy, intravitreal dexamethasone, and intravitreal bevacizumab)

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
David Ehmann, Raul Garcia

Abstract

Age-related macular degeneration is a multifactorial disease involving inflammation, neovascularization, and vascular leakage. As a result, a rationale exists for investigating combination treatments that target the different pathological processes involved in this disease. We propose triple therapy consisting of verteporfin photodynamic therapy (PDT), intravitreal bevacizumab, and intravitreal dexamethasone. Retrospective chart review. Thirty-two eyes of 30 patients were included. None of the patients demonstrated concurrent eye pathology, and none of the patients had received previous treatment for their choroidal neovascularization. One cycle of triple therapy consisted of reduced-fluence PDT (300 mW/cm(2) for 83 seconds to deliver 25 J/cm(2)) followed immediately by an 800 microg (0.08 mL) intravitreal dexamethasone (IVD) injection. At 1 and 7 weeks after PDT and IVD, patients received a 1.25 mg (0.05 mL) bevacizumab injection. At 13 weeks after PDT and IVD, each patient had a repeat optical coherence tomography and fluorescein angiography to assess choroidal neovascularization activity. Patients were followed for 12 months. The mean number of treatment cycles was 1.4. The mean number of bevacizumab injections was 2.8. Visu...Continue Reading

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Citations

Dec 5, 2012·Mediators of Inflammation·Francesco ParmeggianiAdolfo Sebastiani
Mar 20, 2013·International Journal of Inflammation·Ishaq A ViringipurampeerKevin Gregory-Evans
Feb 15, 2014·TheScientificWorldJournal·Valentina SaraoPaolo Lanzetta
Oct 22, 2013·Progress in Retinal and Eye Research·Patrycja Nowak-SliwinskaAdrian H C Koh
Mar 25, 2015·Journal of Ophthalmology·Makoto IshikawaTakeshi Yoshitomi
Apr 25, 2020·International Journal of Molecular Sciences·Pei-Li YaoGoldis Malek
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiaxin LiuFengying Sun

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