Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease

The American Journal of Medicine
Renato D LopesKenneth W Mahaffey

Abstract

The role of triple antithrombotic therapy vs dual antithrombotic therapy in patients with both atrial fibrillation and coronary artery disease remains unclear. This study explores the differences in treatment practices and outcomes between triple antithrombotic therapy and dual antithrombotic therapy in patients with atrial fibrillation and coronary artery disease. Using the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (n = 10,135), we analyzed outcomes in patients with coronary artery disease (n = 1827) according to treatment with triple antithrombotic therapy (defined as concurrent therapy with an oral anticoagulant, a thienopyridine, and aspirin) or dual antithrombotic therapy (comprising either an oral anticoagulant and one antiplatelet agent [OAC plus AA] or 2 antiplatelet drugs and no anticoagulant [DAP]). The use of triple antithrombotic therapy, OAC plus AA, and DAP at baseline was 8.5% (n = 155), 80.4% (n = 1468), and 11.2% (n = 204), respectively. Among patients treated with OAC plus AA, aspirin was the most common antiplatelet agent used (90%), followed by clopidogrel (10%) and prasugrel (0.1%). The use of triple antithrombotic therapy was not affected by patient risk of either stroke or ble...Continue Reading

References

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Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Carl van WalravenDaniel E Singer
Jan 28, 2010·The American Journal of Medicine·Renato D LopesChristopher B Granger
Feb 12, 2011·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN AVERROES Steering Committee and Investigators
Oct 11, 2011·American Heart Journal·Jonathan P PicciniEric D Peterson
Jul 17, 2012·The American Journal of Medicine·Renato D LopesKaren P Alexander
Oct 17, 2012·American Heart Journal·Connie N HessRenato D Lopes
Jun 12, 2013·Journal of the American College of Cardiology·Morten LambertsMorten Lock Hansen

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Citations

Feb 1, 2019·Circulation·Jonathan P PicciniUNKNOWN Get With The Guidelines-AFIB Clinical Working Group and Hospitals
Mar 19, 2019·The New England Journal of Medicine·Renato D LopesUNKNOWN AUGUSTUS Investigators
Jul 2, 2019·Journal of Community Hospital Internal Medicine Perspectives·Waqas Javed SiddiquiHoward Eisen
Jun 24, 2017·Cardiovascular Drugs and Therapy·Dimitrios AlexopoulosJohn Lekakis
Aug 27, 2019·Stroke; a Journal of Cerebral Circulation·Brian Mac GroryMatthew Schrag
Nov 10, 2018·The American Journal of Cardiology·Patrícia O GuimarãesTracy Y Wang
Nov 5, 2019·La Presse médicale·Guillaume CaylaBenoit Lattuca

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