Triplet Excited Carbonyls and Singlet Oxygen Formation During Oxidative Radical Reaction in Skin

Frontiers in Physiology
Ankush PrasadPavel Pospíšil

Abstract

The skin is the largest organ in the body and is consistently exposed to aggressive environmental attacks (biological/physical/chemical, etc.). Reactive oxygen species (ROS) are formed during the normal oxidative metabolism which enhances to a lethal level under stress conditions referred to as oxidative stress. While, under normal conditions, cells are capable of dealing with ROS using non-enzymatic and enzymatic defense system, it can lead to a critical damage to cell system via the oxidation of cellular components under stress condition. Lipid peroxidation is a well-established mechanism of cellular injury in all kinds of organisms and it is often used as an indicator of oxidative stress in cells and tissues. In the presence of metal ions, ROS such as hydrogen peroxide (H2O2) produces highly reactive hydroxyl radical (HO•) via Fenton reaction. In the current study, we have used the porcine skin (intact pig ear/skin biopsies) as an ex vivo/in vitro model system to represent human skin. Experimental results have been presented on the participation of HO• in the initiation of lipid peroxidation and thereby leading to the formation of reactive intermediates and the formation of electronically excited species eventually leading t...Continue Reading

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Citations

Aug 17, 2020·International Journal of Molecular Sciences·Marián MerinoAna Virginia Sánchez-Sánchez
Feb 11, 2020·Frontiers in Chemistry·Érica G A MirandaIseli L Nantes-Cardoso
Oct 7, 2020·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Yu GabeAkira Hachiya
Feb 5, 2021·Journal of Photochemistry and Photobiology. B, Biology·Félix ZapataCarmen García-Ruiz
May 12, 2021·Photochemistry and Photobiology·Nobuyuki HaradaHiroshi Uyama
Jul 3, 2021·Antioxidants·Nicoleta Bianca TudorachiElena Mihaela Cărăuşu
Feb 6, 2019·Chemical Reviews·Paolo Di MascioJean Cadet

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Methods Mentioned

BETA
biopsies
electron paramagnetic resonance
Electron
biopsy

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