Triplet repeat DNA structures and human genetic disease: dynamic mutations from dynamic DNA

Journal of Biosciences
Richard R SindenL S Shlyakhtenko

Abstract

Fourteen genetic neurodegenerative diseases and three fragile sites have been associated with the expansion of (CTG)n (CAG)n, (CGG)n (CCG)n, or (GAA)n (TTC)n repeat tracts. Different models have been proposed for the expansion of triplet repeats, most of which presume the formation of alternative DNA structures in repeat tracts. One of the most likely structures, slipped strand DNA, may stably and reproducibly form within triplet repeat sequences. The propensity to form slipped strand DNA is proportional to the length and homogeneity of the repeat tract. The remarkable stability of slipped strand DNA may, in part, be due to loop-loop interactions facilitated by the sequence complementarity of the loops and the dynamic structure of three-way junctions formed at the loop-outs.

References

Dec 1, 1992·Current Opinion in Biotechnology·R R Sinden, R D Wells
Jan 25, 1992·Nucleic Acids Research·C Schlötterer, D Tautz
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J C HanveyR D Wells
Dec 22, 1986·Nucleic Acids Research·R I MaN C Seeman
Dec 11, 1994·Nucleic Acids Research·C L Semerad, L J Maher
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·D M Lilley
Jan 1, 1994·Annual Review of Biophysics and Biomolecular Structure·N C Seeman, N R Kallenbach
Oct 11, 1994·Nucleic Acids Research·N B UlyanovT L James
Jun 1, 1994·Journal of Biomolecular Structure & Dynamics·L S ShlyakhtenkoY L Lyubchenko
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Fry, L A Loeb
May 1, 1993·Quarterly Reviews of Biophysics·D M Lilley, R M Clegg
Sep 1, 1995·Electrophoresis·S K BrahmachariS Pataskar
Jun 21, 1996·The Journal of Biological Chemistry·J S Godde, A P Wolffe
Jul 12, 1996·The Journal of Biological Chemistry·K OhshimaR D Wells
Jun 15, 1997·Nucleic Acids Research·M Mitas
Nov 14, 1997·Nature Genetics·G M SamadashwilyS M Mirkin
Feb 6, 1998·Journal of Molecular Biology·J M Darlow, D R Leach
Feb 6, 1998·Journal of Molecular Biology·J M Darlow, D R Leach
Feb 19, 1998·Journal of Molecular Biology·P D Chastain, R R Sinden
Jul 17, 1998·Current Opinion in Structural Biology·C E Pearson, R R Sinden

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Citations

Jul 4, 2012·Journal of Biosciences·Sangeeta KunduDhananjay Bhattacharyya
Nov 8, 2003·Trends in Molecular Medicine·Dilip K Nag
Dec 31, 2003·Trends in Genetics : TIG·Lucia Y Brown, Stephen A Brown
Jun 28, 2003·Biophysical Journal·Mikio KatoNobuyoshi Shimizu
Feb 19, 2003·Journal of Molecular Biology·Vladimir N PotamanRichard R Sinden
Dec 12, 2003·Genomics·Frauke NaumannWalter Doerfler
Dec 15, 2010·Biochemistry·Natalya N DegtyarevaJeffrey T Petty
Nov 26, 2009·European Journal of Human Genetics : EJHG·Conceição BettencourtManuela Lima
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jens VölkerKenneth J Breslauer
Feb 26, 2004·Nucleic Acids Research·Michael J Dixon, Robert S Lahue
Mar 16, 2005·Nucleic Acids Research·Lai Man Chi, Sik Lok Lam
Jul 12, 2005·Nucleic Acids Research·Robert D WellsLeslie S Son
Jun 15, 2011·Nucleic Acids Research·Viviana Salinas-RiosPhilip C Hanawalt
Nov 13, 2012·Nucleic Acids Research·Ana AzaGloria Terrados
Mar 26, 2013·Nucleic Acids Research·Long MaDavid T F Dryden
Sep 10, 2004·European Journal of Biochemistry·Xuefeng Pan
Aug 24, 2007·EURASIP Journal on Bioinformatics & Systems Biology·Ravi GuptaKuldip Singh
Mar 1, 2005·BMC Genomics·Carlos Molina, Erich Grotewold
Jul 2, 2009·Journal of the American Chemical Society·Jens VölkerKenneth J Breslauer
May 8, 2009·Science & Justice : Journal of the Forensic Science Society·Andrew J GibbRosalind M Brown
Mar 3, 2007·Seminars in Pediatric Neurology·Richard E Lutz
Jan 30, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mikio KatoNobuyoshi Shimizu
Nov 14, 2008·American Journal of Medical Genetics. Part a·Maria-Mercè Garcia-BarcelóPaul Kwong-hang Tam
May 2, 2013·Medicinal Research Reviews·Jia ShengZhen Huang
Sep 17, 2013·Annals of the New York Academy of Sciences·Lynn Helena Caporale, John Doyle
Feb 21, 2006·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Gail L Rosen
Mar 17, 2006·Biochemical and Biophysical Research Communications·Gargi Ghosal, K Muniyappa
Mar 8, 2006·Mutation Research·M BicharaI B Lambert
Feb 14, 2006·Mutation Research·Seung-Hwan KimRichard R Sinden

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