Triplets, birthweight, and handedness

Proceedings of the National Academy of Sciences of the United States of America
Kauko HeikkiläEero Vuoksimaa

Abstract

The mechanisms behind handedness formation in humans are still poorly understood. Very low birthweight is associated with higher odds of left-handedness, but whether this is due to low birthweight itself or premature birth is unknown. Handedness has also been linked to development, but the role of birthweight behind this association is unclear. Knowing that birthweight is lower in multiple births, triplets being about 1.5 kg lighter in comparison with singletons, and that multiples have a higher prevalence of left-handedness than singletons, we studied the association between birthweight and handedness in two large samples consisting exclusively of triplets from Japan (n = 1,305) and the Netherlands (n = 947). In both samples, left-handers had significantly lower birthweight (Japanese mean = 1,599 g [95% confidence interval (CI): 1,526-1,672 g]; Dutch mean = 1,794 g [95% CI: 1,709-1,879 g]) compared with right-handers (Japanese mean = 1,727 g [95% CI: 1,699-1,755 g]; Dutch mean = 1,903 g [95% CI: 1,867-1,938 g]). Within-family and between-family analyses both suggested that left-handedness is associated with lower birthweight, also when fully controlling for gestational age. Left-handers also had significantly delayed motor dev...Continue Reading

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Citations

May 31, 2019·Laterality·Hiwa Mohammadi, Marietta Papadatou-Pastou
Oct 15, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yoshie Yokoyama
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Apr 4, 2021·International Journal of Environmental Research and Public Health·Jacqueline FagardBarbara Heude
Apr 10, 2021·Cerebral Cortex·Xiang-Zhen KongClyde Francks

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