PMID: 26906357Feb 26, 2016Paper

Triptolide Rescues Spatial Memory Deficits and Amyloid-β Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice

Current Alzheimer Research
Yan-Qiu CuiXiao-Min Wang

Abstract

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by aggregation of amyloid-β (Aβ) peptide in the hippocampus and cortex of brain. Neuroinflammation is considered a driving force of the progression of cognitive decline in AD. During the neuroinflammatory process, activated astrocytes and microglia induced by Aβ peptide produce pro-inflammatory factors and neurotoxins, which promote neurodegeneration in AD brain, eventually dementia. Thus, the suppression of glial over-activation in AD brain might result in therapeutic effect. Triptolide, a natural compound extracted from the Chinese medicinal herb Tripterygium wilfordii Hook F., has shown anti-inflammatory effects. Whether triptolide exhibits preventive effects on AD-like pathology via anti-inflammatory action is unclear. The present study showed that intraperitoneal injection of triptolide (20 μg/kg) for 15 weeks markedly alleviated deficits in learning and memory, and prevented Aβ accumulation in the brain of AD transgenic mice (APP/PS1 mice). These results were accompanied by reduction in glial activation and contents of pro-inflammatory factors in the brain of APP/PS1 mice treated by triptolide compared to saline-treated APP/PS1 mice. In...Continue Reading

Citations

Apr 12, 2017·International Journal of Molecular Sciences·Claire TronelNicolas Arlicot
Dec 16, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Madhuri Ramji Jaiswal, Pravin Popatrao Kale
Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong Kil Lee, Nam-Jung Kim
Mar 14, 2020·Current Pharmaceutical Design·Bapi GorainHira Choudhury
Apr 4, 2021·International Journal of Molecular Sciences·Jacques Hugon, Claire Paquet
Jun 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ou QiaoWenyuan Gao

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