Trisomy 1 in a case of a missed abortion

Journal of Human Genetics
Michio BanzaiHiroshi Kanasugi

Abstract

Most chromosomal trisomies lead to miscarriages. In all trisomies, trisomy 1 is the most rare case. We herein present a patient who demonstrated a gestational sac and a yolk sac on transvaginal ultrasound. However, at 53 days of gestation, the pregnancy was lost with a diagnosis of a blighted ovum. A D&C was recommended and performed. A cytogenetic analysis from chorionic villi demonstrated a 47,XX,+1 chromosome complement in all 100 cells. Regarding full trisomy 1, there has only been one case report of a preembryo and two case reports in a clinically recognized pregnancy to date.

References

Jan 1, 1987·Journal of Medical Genetics·J L WattR O Duncan
Mar 10, 2001·American Journal of Medical Genetics·T M DunnN B Kardon

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Citations

May 31, 2019·Journal of Tissue Engineering and Regenerative Medicine·Sophia FernandesLalita Limaye
Aug 14, 2008·American Journal of Medical Genetics. Part a·Ana VicićFeodora Stipoljev
Oct 17, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Suzhen QuXiangdong Kong
Oct 1, 2005·Journal of Assisted Reproduction and Genetics·Jingly Fung WeierCatherine Racowsky
Nov 1, 2007·European Journal of Human Genetics : EJHG·Barbara R MigeonPatricia A Jacobs
May 4, 2021·Frontiers in Genetics·Chongjuan GuYaojuan He
May 14, 2021·Human Reproduction Update·Geerke M EggenhuizenRobert Jan Galjaard

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