PMID: 8603005Feb 1, 1996Paper

Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia

British Journal of Haematology
S MouldD Oscier

Abstract

Trisomy 12 and deletions or translocations of 13q14 are the commonest cytogenetic abnormalities in chronic lymphocytic leukaemia but rarely co-exist in the same patient. We describe eight patients from a series of > 400 patients with CLL in whom trisomy 12 and t or del 13 occur in the same clone. Using FISH we have identified clones with trisomy 12 alone, t or del 13q14 alone and both abnormalities, in each of the patients studied. This implies that neither trisomy 12 nor t or del 13q14 is the initiating event in leukaemogenesis, but does not exclude the possibility of a submicroscopic abnormality of 13q14 occurring as an early event.

Citations

Sep 4, 1999·Leukemia Research·P StarostikM Albitar
Apr 1, 1997·Cancer Genetics and Cytogenetics·K F Wong, C C So
Mar 1, 1997·Cancer Genetics and Cytogenetics·J DierlammD K Hossfeld
Mar 1, 1997·Cancer Genetics and Cytogenetics·J A Garcia-MarcoD Catovsky
Jan 15, 1998·Cancer Genetics and Cytogenetics·H Acar, M J Connor
Feb 25, 2000·Current Opinion in Oncology·R Bannerji, J C Byrd
Apr 8, 1999·Leukemia & Lymphoma·A CrielC De Wolf-Peeters
Dec 19, 2006·Cancer Genetics and Cytogenetics·Lai-Ching LauBoon-Chai Koh Mickey
Nov 25, 1997·Blood Reviews·T J Hamblin, D G Oscier
Feb 9, 2019·Molecular Cytogenetics·María Paulina Nava-RodríguezJuan Ramón González-García

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