PMID: 9631588Jun 19, 1998Paper

Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

International Journal of Hematology
K KojimaT Sezaki

Abstract

We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cell with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.

Citations

Aug 25, 2010·Advances in Anatomic Pathology·Michele Roullet, Adam Bagg
Oct 8, 2014·Clinical Medicine Insights. Pathology·Ghaleb ElyamanyAbdulaziz Al-Abulaaly
Nov 29, 2002·Archives of Pathology & Laboratory Medicine·Filiz SenMaher Albitar

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