Trisomy 18 and Congenital Heart Disease: Single-Center Review of Outcomes and Parental Perspectives

World Journal for Pediatric & Congenital Heart Surgery
Neena A DavissonRobert D Tunks

Abstract

In patients with trisomy 18, congenital heart surgery is controversial due to anticipated poor patient outcome. Data are lacking regarding clinical outcomes and family opinions about care received. A retrospective chart review of patients with trisomy 18 and congenital heart disease from 2005 to 2017 was performed. Patients were grouped into those receiving cardiac intervention (surgery or cardiac catheterization) versus medical management. A telephone survey was used to assess completeness of family counseling provided prior to treatment selection and parental opinions on the care received. Seventeen infants were assessed. In the medical management group (n = 7), there were five deaths at a median age of 1.5 months (range: 1.2-4.1 months) and two survivors aged 29 and 44 months at latest follow-up. In the intervention group (n = 10), cardiac surgery was performed in nine patients at a median age of 4.3 months (0.2-23.4 months) and weight of 3.2 kg (1.5-12.2 kg); catheter intervention was performed in one patient at one week of age. At latest follow-up, seven intervention patients are alive at a median age of 50 months (5-91 months). Survey respondents (n = 12) unanimously stated that their child's quality of life was improved ...Continue Reading

References

Mar 17, 2004·The American Journal of Cardiology·Eric M GrahamUNKNOWN Pediatric Cardiac Care Consortium
May 10, 2006·Journal of Applied Genetics·Barbara GocJanusz Swietliński
Apr 3, 2009·Pediatric Cardiology·Yukihiro KanekoTadashi Kawakami
Jan 6, 2011·Cardiology in the Young·Jun MuneuchiKunitaka Joo
May 19, 2011·Journal of Genetic Counseling·Andrew R YatesKim L McBride
Oct 13, 2011·American Journal of Medical Genetics. Part a·Jun MaedaToshio Nakanishi
Jul 25, 2012·Pediatrics·Annie JanvierBenjamin S Wilfond
Oct 24, 2012·Orphanet Journal of Rare Diseases·Anna Cereda, John C Carey
May 1, 2017·The Annals of Thoracic Surgery·Jennifer K PetersonShaun P Setty
Oct 20, 2017·Pediatrics·Katherine A KosivR Thomas Collins

❮ Previous
Next ❯

Citations

Jan 23, 2020·Cardiology in the Young·Meaghann S WeaverJames Hammel
Sep 15, 2020·Pediatric Cardiology·Horacio G CarvajalPirooz Eghtesady
Nov 20, 2020·Cardiology in the Young·Meaghann S WeaverAnnie Janvier
Aug 8, 2021·The Journal of Pediatrics·Tyler A Fick, S Kristen Sexson Tejtel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.