Trisomy of chromosome R confers resistance to triazoles in Candida albicans

Medical Mycology
Xingxing LiYuanying Jiang

Abstract

Genome plasticity is a hallmark of Candida albicans, and it has been suggested that it generates numerical and structural genomic variations as a means of adaptation. In this study, we used array based comparative genomic hybridization technology and the quantitative real time PCR to investigate the mechanisms by which the following strains obtained by genetic manipulation, CaLY188, CaLY350, CaLY190 and CaLY191, were resistant to antifungal azoles. All four showed trisomy of chromosome R and resistance to azoles. Serial passage of CaLY188 in drug-free medium resulted in chromosome loss, causing chromosome R disomy and loss of azole resistance. Thus we proposed that trisomy of chromosome R contributes to azole resistance.

References

Jul 22, 2006·Science·Anna SelmeckiJudith Berman
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Mar 28, 2008·Molecular Microbiology·Anna SelmeckiJudith Berman
May 25, 2010·Eukaryotic Cell·Anna SelmeckiJudith Berman
May 3, 2011·Biological & Pharmaceutical Bulletin·Feng YangYuan-Ying Jiang
Mar 3, 2012·Microbiological Research·Lan YanMalcolm Whiteway

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Citations

Nov 23, 2018·Genetics·Douda BensassonStephen A James
Jun 13, 2020·Antibiotics·Somanon BhattacharyaBettina C Fries
May 10, 2019·Frontiers in Microbiology·Jingxiang ZhangYuanying Jiang
Oct 12, 2019·The Journal of Antimicrobial Chemotherapy·Andrew T NishimotoP David Rogers
Oct 7, 2021·Microbiology Spectrum·Feng YangYuan-Ying Jiang

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