PMID: 6162754Jan 1, 1980Paper

Trisomy of the long arm of chromosome in a patient with primary myelofibrosis during blast crisis

Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
I BaravikaL Jaworkowsky

Abstract

The caryotype of a patient't leukemic cells with primary myelofibrosis being at the stage of blast crisis is described. In all cells examined a great submetacentric chromosome was detected which was formed by the duplication of the whole long arm of the first chromosome. The second chromosome of the first pair remained unchanged. Moreover, there was no sexual chromosome Y in seven metaphase plates. The significance of these and other changes of the first chromosome in the genesis of some malign diseases is discussed.

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