Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Andreas KoeberleOliver Werz

Abstract

Age-related diseases, such as osteoarthritis, Alzheimer's disease, diabetes, and cardiovascular disease, are often associated with chronic unresolved inflammation. Neutrophils play central roles in this process by releasing tissue-degenerative proteases, such as cathepsin G, as well as pro-inflammatory leukotrienes produced by the 5-lipoxygenase (5-LO) pathway. Boswellic acids (BAs) are pentacyclic triterpene acids contained in the gum resin of the anti-inflammatory remedy frankincense that target cathepsin G and 5-LO in neutrophils, and might thus represent suitable leads for intervention with age-associated diseases that have a chronic inflammatory component. Here, we investigated whether, in addition to BAs, other triterpene acids from frankincense interfere with 5-LO and cathepsin G. We provide a comprehensive analysis of 17 natural tetra- or pentacyclic triterpene acids for suppression of 5-LO product synthesis in human neutrophils. These triterpene acids were also investigated for their direct interference with 5-LO and cathepsin G in cell-free assays. Furthermore, our studies were expanded to 10 semi-synthetic BA derivatives. Our data reveal that besides BAs, several tetra- and pentacyclic triterpene acids are effective ...Continue Reading

References

Apr 3, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lutz FischerOliver Werz
Dec 16, 2006·Current Medicinal Chemistry·Daniel Poeckel, Oliver Werz
Jul 7, 2007·Sub-cellular Biochemistry·K D Rainsford
Aug 12, 2008·Biochemical Pharmacology·Thorsten J MaierGerd Geisslinger
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars TauschOliver Werz
May 11, 2011·Clinical Pharmacokinetics·Mona Abdel-TawabManfred Schubert-Zsilavecz
Jan 12, 2013·Science·Ira Tabas, Christopher K Glass
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Claudio Franceschi, Judith Campisi
Sep 13, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arne HenkelOliver Werz

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
S SinghG N Qazi
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Arne HenkelOliver Werz
Current Medicinal Chemistry
Daniel Poeckel, Oliver Werz
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
H P Ammon
© 2022 Meta ULC. All rights reserved