Triterpenoid-Mediated Inhibition of Virus-Host Interaction: Is Now the Time for Discovering Viral Entry/Release Inhibitors from Nature?

Journal of Medicinal Chemistry
Haiwei LiDemin Zhou

Abstract

Fatal infectious diseases caused by HIV-1, influenza A virus, Ebola virus, and currently pandemic coronavirus highlight the great need for the discovery of antiviral agents in mechanisms different from current viral replication-targeted approaches. Given the critical role of virus-host interactions in the viral life cycle, the development of entry or shedding inhibitors may expand the current repertoire of antiviral agents; the combination of antireplication inhibitors and entry or shedding inhibitors would create a multifaceted drug cocktail with a tandem antiviral mechanism. Therefore, we provide critical information about triterpenoids as potential antiviral agents targeting entry and release, focusing specifically on the emerging aspect of triterpenoid-mediated inhibition of a variety of virus-host membrane fusion mechanisms via a trimer-of-hairpin motif. These properties of triterpenoids supply their host an evolutionary advantage for chemical defense and may protect against an increasingly diverse array of viruses infecting mammals, providing a direction for antiviral drug discovery.

References

Dec 1, 1981·The Journal of Cell Biology·K S MatlinK Simons
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·M R Berenbaum
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J F MayauxE De Clercq
Nov 1, 1993·AIDS Research and Human Retroviruses·C WildT Matthews
Mar 1, 1996·Journal of Medicinal Chemistry·Y KashiwadaK H Lee
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·H GaroffD J Opstelten
Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·I C SunK H Lee
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·V N MalashkevichP S Kim
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·K PapadopoulouA E Osbourn
Mar 7, 2001·Science·M J RootP S Kim
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·D M Eckert, P S Kim
Oct 2, 2001·Cellular and Molecular Life Sciences : CMLS·C Boucheix, E Rubinstein
Sep 20, 2002·Journal of Virology·Sara B Sieczkarski, Gary R Whittaker
Mar 15, 2003·The New England Journal of Medicine·Jacob P LalezariUNKNOWN TORO 1 Study Group
Oct 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·F LiC T Wild
Mar 27, 2004·Nature Reviews. Microbiology·Dimiter S Dimitrov
May 4, 2004·Nature Structural & Molecular Biology·Michael J RustXiaowei Zhuang
Jul 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chung-Yi WuChi-Huey Wong
Feb 18, 2005·Journal of Medicinal Chemistry·Gerold HoeverJindrich Cinatl
Jun 7, 2005·Trends in Microbiology·Mya Breitbart, Forest Rohwer
Jul 5, 2005·Journal of Ethnopharmacology·Jie Liu
Nov 30, 2005·Bioorganic & Medicinal Chemistry·Li HuangChin-Ho Chen
Dec 21, 2005·Virology·Margaret Kielian
Feb 25, 2006·Cell·Mark Marsh, Ari Helenius
May 24, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sami AlakurttiJari Yli-Kauhaluoma
Jun 3, 2006·Natural Product Reports·Petr DzubakJan Sarek
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Pei-Win ChengChun-Ching Lin
Sep 1, 2006·Journal of Medicinal Chemistry·Donglei YuKuo-Hsiung Lee
Sep 21, 2006·Biology Direct·Eugene V KooninValerian V Dolja
Feb 10, 2007·Science·Stéphane RocheStéphane Bressanelli
Feb 27, 2007·FEBS Letters·Winfried WeissenhornYves Gaudin

❮ Previous
Next ❯

Citations

Apr 23, 2021·Analytical Methods : Advancing Methods and Applications·Yi Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.