Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiao-Yang WangHai-Feng Tang

Abstract

Five previously undescribed triterpenoid saponins (1-5), along with eight known ones (6-13), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC50 values of 18.21 and 15.56 μM, respectively.

References

Nov 1, 1994·Phytochemistry·C MaedaK Q Nguyen
Jan 1, 1997·Phytochemistry·M K WangY Z Chen
Mar 17, 1999·Journal of Natural Products·W YeS Zhao
Aug 10, 1999·Journal of Gastroenterology and Hepatology·D Li, S L Friedman
Oct 3, 2000·Phytochemistry·S M Abdel KhalikF R Melek
Jun 1, 2001·Chemical & Pharmaceutical Bulletin·W C YeC T Che
Sep 29, 2001·Journal of Natural Products·Y MimakiY Sashida
Apr 24, 2004·Journal of Natural Products·Quan ZhengTamotsu Nikaido
Sep 25, 2004·Journal of Natural Products·Yoshihiro MimakiYutaka Sashida
Nov 13, 2007·Journal of Asian Natural Products Research·Tun-Hai XuDong-Ming Xu
Dec 17, 2008·Fitoterapia·Xin ChenHiroyuki Kodama
Jul 3, 2009·Chemical & Pharmaceutical Bulletin·Yoshihiro MimakiHiroshi Sakagami
Aug 31, 2010·Phytochemistry·Heejung YangSang Hyun Sung
Feb 25, 2011·Planta medica·Xiao-Yang WangPing-Hu Zhang
Mar 7, 2012·Journal of Natural Medicines·Yi WangXiang-rong Tian
Sep 3, 2013·Bioorganic & Medicinal Chemistry Letters·Xiao-Yang WangHai-Feng Tang
Nov 26, 2013·Phytochemistry·Milena MasulloSonia Piacente
Feb 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaoyang WangXiaoli Sun
May 30, 2015·Journal of Asian Natural Products Research·Hui LiHai-Feng Tang
Jun 6, 2016·Phytochemistry·Min ZhaoYan Zhou
Dec 1, 2017·Natural Product Research·Xiao ZhangLiang Xiong

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Methods Mentioned

BETA
NMR
glycosylation
column chromatography
PCR

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