Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory, anti-fungal and anti-leishmanial activities

Phytochemistry
Athar AtaBilge Sener

Abstract

From the aerial parts of Buxus hyrcana, three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine (1), buxhyrcamine (2), and 31-demethylcyclobuxoviridine (3), along with 16 known compounds, cyclobuxoviridine (4), N(b)-dimethylcyclobuxoviricine (5), E-buxenone (6), Z-buxenone (7), moenjodaramine (8), homomoenjodarmine (9), buxamine A (10), buxamine B (11), 31-hydroxybuxamine B (12), N(20)-formylbuxaminol E (13), papillozine C (14), buxmicrophylline F (15), buxrugulosamine (16), cyclobuxophylline O (17), spirofornabuxine (18) and arbora-1,9(11)-dien-3-one (19) were isolated. Their structures were elucidated by using NMR spectroscopic methods. All of the compounds exhibited moderate to weak acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase inhibitory activities. Compounds 1-19 also exhibited modest anti-fungal activities against Candidaalbicans. Compounds 1, 2, 8, 9 and 18 also exhibited weak anti-leishmanial activity.

Citations

Mar 16, 2013·Chemistry & Biodiversity·Anthony A AgomuohIwu Irenus
Nov 19, 2013·The Journal of Pharmacy and Pharmacology·Eduardo Luis KonrathAmélia T Henriques
Sep 14, 2015·Chemistry & Biodiversity·Jie ZhangJian-Jun Fu
Dec 22, 2014·Steroids·Cheuk W LamSamir A Ross
Jun 12, 2016·Chemistry & Biodiversity·David GraceAthar Ata
Jan 1, 2016·Journal of Food and Drug Analysis·Hossein DehghanPeyman Salehi
Jan 23, 2021·Pharmaceutics·Maria D AuxteroAna I Fernandes
Mar 3, 2021·Bioorganic Chemistry·Zhi-Nan XiangLuo-Sheng Wan
Oct 20, 2010·Journal of Natural Products·Wadim L MatochkoRobert M Gengan

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