Tritrichomonas foetus and Trichomonas vaginalis: the pattern of inactivation of hydrogenase activity by oxygen and activities of catalase and ascorbate peroxidase.

Microbiology
Madhu Page-SharpGeoffrey D Smith

Abstract

The concentration-dependence of the inhibition of whole-cell hydrogen formation by oxygen has been measured in the trichomonads Trichomonas vaginalis and Tritrichomonas foetus, and compared with the oxygen inhibition of the in situ hydrogenase activity as measured by a tritium exchange assay. The inhibition profiles closely paralleled each other, suggesting that hydrogenase is the primary site of inhibition of anaerobic fermentative metabolism. In addition the inhibition profile for isolated hydrogenosomes was measured and shown to be similar to that for whole organisms. Ascorbate peroxidase was shown to be present in both organisms whereas catalase was confirmed to be present only in Tritr. foetus. The kinetic parameters of both enzymes were measured and their respective roles in oxygen protection discussed.

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May 22, 2013·International Journal for Parasitology·Sven B GouldWilliam F Martin
Sep 23, 1997·Molecular and Biochemical Parasitology·B L GrangerM Owhashi
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Jan 31, 2020·Microbiology and Molecular Biology Reviews : MMBR·Stéphane L BenoitChris Greening
Jun 13, 2017·Molecular and Biochemical Parasitology·Shuqi E WangAugusto Simoes-Barbosa

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