PMID: 9535101Apr 16, 1998Paper

Trk neurotrophin receptor family immunoreactivity in rat and human pituitary tissues

Neuroscience Letters
F AguadoI Ferrer

Abstract

Several lines of evidence suggest that neurotrophins may be involved in pituitary function. By immunocytochemical methods we analyzed the cellular distribution of their functional receptors in the pituitary gland. In the rat pituitary gland Trks were differentially distributed. Punctate immunoreactivity for TrkA was observed within the neural lobe, whereas numerous nerve endings were immunostained for TrkB and TrkC in the intermediate lobe. Endocrine cells of the intermediate lobe exhibited intense immunoreactivity for the three Trks, whereas scattered endocrine cells of the anterior lobe displayed a robust immunostaining for TrkC. In addition, TrkA and TrkB immunoreactivity was located in normal and neoplastic endocrine cells from human pituitary adenomas. The differential distribution of Trks in the hypophysis suggests a potential role of different neurotrophins in pituitary functions.

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Citations

May 16, 2000·Brain Research Bulletin·L C SalandJ Gaddy
Jul 24, 2010·Endocrine Reviews·Stanko S StojilkovicRichard Bertram
Apr 6, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Yossef S LevyDaniel Offen
Dec 22, 1999·Endocrine Research·M C Amoureux
Apr 18, 2012·International Journal of Immunopathology and Pharmacology·M ArticoL Fumagalli
Oct 29, 2005·Molecular and Cellular Neurosciences·Elia Benito-GutiérrezJoan X Comella
Jun 14, 2006·Neurobiology of Aging·Florence RageLucia Tapia-Arancibia

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