tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA

Genes
Siqi LiJinghao Sheng

Abstract

Deep analysis of next-generation sequencing data unveils numerous small non-coding RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA-derived small RNA (tsRNA), have attracted broad attention. There are mainly two types of tsRNAs, including tRNA-derived stress-induced RNA (tiRNA) and tRNA-derived fragment (tRF), which differ in the cleavage position of the precursor or mature tRNA transcript. Emerging evidence has shown that tsRNAs are not merely tRNA degradation debris but have been recognized to play regulatory roles in many specific physiological and pathological processes. In this review, we summarize the biogeneses of various tsRNAs, present the emerging concepts regarding functions and mechanisms of action of tsRNAs, highlight the potential application of tsRNAs in human diseases, and put forward the current problems and future research directions.

References

Jan 1, 1976·Annual Review of Biochemistry·A Rich, U L RajBhandary
Dec 1, 1979·Cancer·J SpeerE Borek
Apr 21, 1999·Current Biology : CB·G Simos, E Hurt
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TomitaH Masaki
Nov 24, 2004·Neurology·M J GreenwayO Hardiman
Nov 8, 2005·The Journal of Biological Chemistry·Suzanne R Lee, Kathleen Collins
Mar 17, 2007·Nature Reviews. Genetics·R Keith Slotkin, Robert Martienssen
May 8, 2007·Cell·Brian Keith, M Celeste Simon
Dec 18, 2007·Nucleic Acids Research·Henry J HaiserMarie A Elliot
Dec 31, 2008·FEBS Letters·Hanjiang FuXiaofei Zheng
Apr 1, 2009·The Journal of Cell Biology·Satoshi YamasakiPaul Anderson
Apr 1, 2009·The Journal of Cell Biology·Debrah M Thompson, Roy Parker
Nov 12, 2009·FEBS Letters·Rajat BanerjeeMichael Ibba
Nov 26, 2009·Genes & Development·Yong Sun LeeAnindya Dutta
Feb 17, 2010·Molecular and Biochemical Parasitology·Maria Rosa Garcia-SilvaAlfonso Cayota
Mar 17, 2010·Molecular Cell·Yide MeiXiaolu Yang
Aug 4, 2010·Genes & Development·Matthias SchaeferFrank Lyko
May 17, 2011·Wiley Interdisciplinary Reviews. RNA·Richard J Maraia, Tek N Lamichhane
Aug 23, 2011·Molecular Cell·Pavel IvanovPaul Anderson
Jul 31, 2012·Nucleic Acids Research·Anne DueckGunter Meister
Aug 14, 2012·Nature Structural & Molecular Biology·Francesca TuortoFrank Lyko
Aug 22, 2012·Annual Review of Genetics·Basma El YacoubiValérie de Crécy-Lagard
Sep 20, 2012·Memórias do Instituto Oswaldo Cruz·Larissa ReifurBruno Dallagiovanna
Oct 23, 2012·The Journal of Biological Chemistry·Mridusmita SaikiaMaria Hatzoglou
Nov 28, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qingrong WangXiaoyong Bao
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roy L MauteRiccardo Dalla-Favera
Jan 18, 2013·Archaea : an International Microbiological Journal·Jennifer GebetsbergerNorbert Polacek
Apr 23, 2014·Molecular and Cellular Biology·Mridusmita SaikiaMaria Hatzoglou
May 17, 2014·Journal of the American Society of Nephrology : JASN·Eikan MishimaTakaaki Abe

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Citations

Feb 26, 2019·Journal of Cellular and Molecular Medicine·Hui ChenDeliang Liu
Feb 20, 2019·Non-coding RNA·Shengqian DouJian Lu
Nov 19, 2019·Database : the Journal of Biological Databases and Curation·Alessandro La FerlitaAlfredo Pulvirenti
Jan 9, 2020·ACR Open Rheumatology·Michelle J OrmsethC Michael Stein
Feb 12, 2020·Journal of Bacteriology·Ben TurnerDirk Iwata-Reuyl
Sep 29, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maurizio FalconiAugusto Amici
May 20, 2020·International Journal of Cancer. Journal International Du Cancer·Tianyu ZengYongmei Yin
May 1, 2019·The Journal of Clinical Investigation·Marion C HoggJochen Hm Prehn
Oct 11, 2019·Precision Clinical Medicine·Qinqin PuMin Wu
Nov 23, 2019·Cells·Christiaan J Stavast, Stefan J Erkeland
Sep 16, 2020·Nature Metabolism·Joji KusuyamaLaurie J Goodyear
Aug 20, 2020·Circulation. Genomic and Precision Medicine·Saumya DasUNKNOWN American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular B
Sep 21, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yijing ShenJunming Guo
May 20, 2019·Cancer Biomarkers : Section a of Disease Markers·Linwen ZhuJunming Guo
Nov 2, 2019·Journal of Cellular Biochemistry·Zhongliang MaYanli Li
Mar 29, 2020·Clinical Science·Jinhui LüRichard G Pestell
Apr 10, 2019·Wiley Interdisciplinary Reviews. RNA·Sarah ResselAmy H Buck
Sep 26, 2019·Neural Regeneration Research·Chuan QinJian-Jun Li
Jan 16, 2020·International Journal of Molecular Medicine·Yaping ZhangDewu Liu
Jul 2, 2020·Signal Transduction and Targeted Therapy·Yaoyao XieJunming Guo
Oct 1, 2020·International Journal of Molecular Sciences·Dylan J Kiltschewskij, Murray J Cairns
Oct 1, 2020·Cancers·Joonhyeong ParkSuhwan Chang
Sep 23, 2020·Annals of the Rheumatic Diseases·Michelle J OrmsethC Michael Stein
Nov 17, 2020·Frontiers in Genetics·Anahi Molla-HermanJean-René Huynh
Sep 2, 2020·Annual Review of Genetics·Erin K BorchardtWendy V Gilbert
Dec 18, 2020·Briefings in Bioinformatics·A T Vivek, Shailesh Kumar
Nov 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yueying Chen, Jun Shen
Dec 31, 2020·International Journal of Molecular Sciences·T Truc My NguyenAnne Yaël Nossent
Dec 18, 2020·Frontiers in Oncology·Tiziana AnneseDomenico Ribatti
Jan 10, 2021·International Journal of Molecular Sciences·Maria Nicol ArroyoMariana Igoillo-Esteve
Dec 17, 2020·MBio·Jessica M TuckerBritt A Glaunsinger

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tsRNA

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