tRNA methylation: An unexpected link to bacterial resistance and persistence to antibiotics and beyond.

Wiley Interdisciplinary Reviews. RNA
Ya-Ming HouLeonard J Foster

Abstract

A major threat to public health is the resistance and persistence of Gram-negative bacteria to multiple drugs during antibiotic treatment. The resistance is due to the ability of these bacteria to block antibiotics from permeating into and accumulating inside the cell, while the persistence is due to the ability of these bacteria to enter into a nonreplicating state that shuts down major metabolic pathways but remains active in drug efflux. Resistance and persistence are permitted by the unique cell envelope structure of Gram-negative bacteria, which consists of both an outer and an inner membrane (OM and IM, respectively) that lay above and below the cell wall. Unexpectedly, recent work reveals that m1 G37 methylation of tRNA, at the N1 of guanosine at position 37 on the 3'-side of the tRNA anticodon, controls biosynthesis of both membranes and determines the integrity of cell envelope structure, thus providing a novel link to the development of bacterial resistance and persistence to antibiotics. The impact of m1 G37-tRNA methylation on Gram-negative bacteria can reach further, by determining the ability of these bacteria to exit from the persistence state when the antibiotic treatment is removed. These conceptual advances ra...Continue Reading

References

Jun 1, 1991·Journal of Bacteriology·K Young, L L Silver
Feb 1, 1989·Antimicrobial Agents and Chemotherapy·D M ShlaesR Williamson
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J V Höltje
Aug 26, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H Nikaido
Mar 6, 1999·Current Opinion in Microbiology·H Nikaido
Apr 16, 2002·Molecular Microbiology·R Allyn ForsythJudith W Zyskind
Mar 27, 2003·Molecular Microbiology·Christopher M SassettiEric J Rubin
May 30, 2003·The EMBO Journal·Hyung Jun AhnJin Kuk Yang
Oct 30, 2003·Journal of Molecular Biology·Patricia A ElkinsWalter M Holmes
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Hiroshi Nikaido
May 29, 2004·Journal of Molecular Biology·Thomas ChristianYa-Ming Hou
Feb 22, 2005·Molecular Microbiology·Christina Tam, Dominique Missiakas
Apr 27, 2005·Cell·Natividad RuizThomas J Silhavy
Oct 20, 2006·Nature·Gulnara YusupovaMarat Yusupov
Sep 18, 2007·Journal of Molecular Biology·Thomas Christian, Ya-Ming Hou
Mar 6, 2008·Molecular Systems Biology·Véronique de BerardinisJean Weissenbach
Apr 4, 2008·Proteins·Sakurako Goto-ItoShigeyuki Yokoyama
Jul 17, 2008·Comparative and Functional Genomics·Thomas A White, Douglas B Kell
Sep 15, 2009·Nature Structural & Molecular Biology·Sakurako Goto-ItoShigeyuki Yokoyama
May 11, 2010·Journal of Molecular Biology·Thomas ChristianYa-Ming Hou
Dec 18, 2010·Nature Reviews. Microbiology·Julian G HurdleRichard E Lee
Jan 15, 2011·Clinical Microbiology Reviews·Lynn L Silver
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Sandro F F PereiraJonathan Dworkin
Dec 29, 2011·Nature Reviews. Microbiology·Athanasios TypasWaldemar Vollmer
Jun 4, 2013·Molecular Cell·Erik GutierrezThomas E Dever
Oct 24, 2013·Current Opinion in Microbiology·Ge ZhangDaniel Kahne
May 27, 2015·Nature Communications·Howard B GamperYa-Ming Hou
Jul 4, 2015·Nature Reviews. Drug Discovery·Ruben TommasiAlita A Miller
Jul 4, 2015·International Journal of Molecular Sciences·Howard B GamperYa-Ming Hou
Jul 18, 2015·Proceedings of the National Academy of Sciences of the United States of America·Takuhiro ItoShigeyuki Yokoyama
Sep 24, 2015·Journal of Chemical Information and Modeling·Virginie Y MartinyBogdan I Iorga
Mar 1, 2016·ACS Infectious Diseases·Helen I ZgurskayaS Gnanakaran
Apr 16, 2016·Nature Reviews. Microbiology·Asher BraunerNathalie Q Balaban

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Adamantia KouvelaVassiliki Stamatopoulou
Nov 12, 2021·Nucleic Acids Research·Ben E CliftonPaola Laurino
Dec 17, 2021·Wiley Interdisciplinary Reviews. RNA·Yuri Motorin, Mark Helm

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.