PMID: 9182803May 1, 1997Paper

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret

Neuron
R H BalohJ Milbrandt

Abstract

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) comprise a family of TGF-beta-related neurotrophic factors (TRNs), which have trophic influences on a variety of neuronal populations. A receptor complex comprised of TrnR1 (GDNFR alpha) and Ret was recently identified and found to be capable of mediating both GDNF and NTN signaling. We have identified a novel receptor based on homology to TrnR1, called TrnR2, that is 48% identical to TrnR1, and is located on the short arm of chromosome 8. TrnR2 is attached to the cell surface via a GPI-linkage, and can mediate both NTN and GDNF signaling through Ret in vitro. Fibroblasts expressing TrnR2 and Ret are approximately 30-fold more sensitive to NTN than to GDNF treatment, whereas those expressing TrnR1 and Ret respond equivalently to both factors, suggesting the TrnR2-Ret complex acts preferentially as a receptor for NTN. TrnR2 and Ret are expressed in neurons of the superior cervical and dorsal root ganglia, and in the adult brain. Comparative analysis of TrnR1, TrnR2, and Ret expression indicates that multiple receptor complexes, capable of mediating GDNF and NTN signaling, exist in vivo.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·L LiL J Houenou
Jan 1, 1995·Annual Review of Biochemistry·S Udenfriend, K Kodukula
Jan 26, 1995·Nature·R M Lindsay
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·D O Clary, L F Reichardt
Feb 1, 1994·The Journal of Cell Biology·S N Edwards, A M Tolkovsky
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·W M Barnes
Mar 21, 1996·Nature·D M GashG A Gerhardt
Jun 27, 1996·Nature·P DurbecM Saarma
Jul 4, 1996·Nature·M W MooreA Rosenthal
Jul 4, 1996·Nature·J J TreanorA Rosenthal
Feb 7, 1997·Science·D L Choi-LundbergM C Bohn
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·D J CreedonE M Johnson

❮ Previous
Next ❯

Citations

Aug 14, 1998·The Journal of Comparative Neurology·J P GoldenE M Johnson
Jun 26, 1999·Microscopy Research and Technique·M Saarma, H Sariola
Feb 12, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K LuukkoI Thesleff
Oct 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K LuukkoI Thesleff
May 14, 1999·Developmental Genetics·J A DaviesJ Milbrandt
Mar 10, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A GarcèsO Delapeyrière
Dec 18, 2001·The Journal of Comparative Neurology·A JosephsonC Spenger
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M SukumaranV Pachnis
Jun 15, 2006·Journal of Molecular Histology·Chunhua YangDinah W Y Sah
Jan 27, 2004·Brain Research. Developmental Brain Research·Robert Riddle, Jonathan D Pollock
Mar 23, 2004·Molecular and Cellular Neurosciences·Mikhail PavelievMart Saarma
Apr 10, 2003·Experimental Neurology·Adam C LipsonLars Olson
Oct 24, 1998·Trends in Neurosciences·C F Ibáñez
Nov 5, 2002·Brain Research. Molecular Brain Research·Nazanin F DolatshadM Jill Saffrey
Mar 30, 1999·Brain Research. Molecular Brain Research·L FengB Lu
Mar 17, 2000·Brain Research. Molecular Brain Research·T StöverM I Lomax
Mar 12, 2004·Cancer Letters·Masatoshi IchiharaMasahide Takahashi
May 29, 2002·Brain Research Bulletin·E Arenas
Sep 12, 2001·Pediatric Neurology·B ZhouJ M Gitschier
Jan 13, 1998·Current Opinion in Cell Biology·H Sariola, K Sainio
Feb 19, 2000·Current Opinion in Neurobiology·R H BalohJ Milbrandt
Sep 7, 2001·Cytokine & Growth Factor Reviews·M Takahashi
Jul 15, 2005·Cell Death and Differentiation·D E BredesenS Rabizadeh
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mehdi GasmiRaymond T Bartus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.