PMID: 11920584Mar 29, 2002Paper

Troglitazione affects survival of human osteosarcoma cells

International Journal of Cancer. Journal International Du Cancer
Enrico LucarelliPiero Picci

Abstract

Activation of PPAR gamma, a transcription factor member of the family of peroxisome proliferator-activated receptors, induces apoptosis in several normal and tumor cell lines. In our study, we investigated whether treatment with troglitazone (TRO), a known PPAR gamma agonist, induced apoptosis in the human osteosarcoma (OS) cell lines G292, MG63, SAOS and U2OS that express PPAR gamma. In our experiments, TRO never induced apoptosis of OS cells; on the contrary, TRO increased cell number, based on MTT proliferation assay. Remarkably, the TRO-induced cell number increase depended on a decrease of apoptosis that naturally occurred in the culture and was not due to an increased cell proliferation rate. TRO also prevented staurosporin-induced apoptosis. The TRO-mediated survival effect correlated with the activation of Akt, a well-known mediator of survival stimuli. Our work describes a new function for TRO and indicates that the Akt survival pathway may be a mediator of TRO-induced increase of survival.

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Citations

Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ellen FridayFrancesco Turturro
Feb 7, 2009·PPAR Research·Martin B OleksiewiczFrederikke L Egerod
Feb 26, 2010·PPAR Research·Eric R WagnerRex C Haydon
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Efstathia PapageorgiouMichael Koutsilieris
Dec 4, 2003·Expert Opinion on Investigational Drugs·Dipak PanigrahyArja Kaipainen
Jan 25, 2007·Expert Opinion on Investigational Drugs·Costas GiaginisStamatios Theocharis
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May 25, 2007·Fundamental & Clinical Pharmacology·Costas GiaginisStamatios Theocharis
Sep 24, 2008·Journal of Cellular Biochemistry·Flavia Q PirihSotirios Tetradis
Jul 27, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·G MabilleauM E Edmonds
May 17, 2008·PPAR Research·Christian FreudlspergerJürgen Hoffmann
Dec 3, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marjorie A PerazaJeffrey M Peters
Apr 10, 2004·The Journal of Biological Chemistry·Liping XiaoMarja M Hurley

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis