Abstract
To introduce troglitazone (CS-045, Rezulin), a new oral antidiabetic agent and discuss its pharmacology, therapeutics, pharmacokinetics, dosing guidelines, adverse effects, drug interactions, and clinical efficacy. A MEDLINE database search was completed to identify relevant articles including reviews, recent studies and abstracts, and data from Parke-Davis. Due to the small number of published human studies available, some data are derived from animal studies and abstracts of human studies. Studies and abstracts chosen summarize the clinical action of troglitazone in healthy volunteers, in subjects with impaired glucose tolerance, and in patients with diabetes mellitus. Three of the six published human studies used subjects in a placebo-controlled, multicenter, randomized environment (type 2 diabetic patients or obese subjects with insulin resistance). All clinical trials available, including unpublished reports, were reviewed. Troglitazone is the first member of a new class of medications, the thiazolidinediones, to be approved for clinical use. Troglitazone increases insulin sensitivity in skeletal muscle and in hepatic and adipose tissue. It has been shown to decrease hepatic glucose output while having no effect on stimula...Continue Reading
References
Jan 1, 1976·The American Journal of Medicine·G M ReavenJ M Olefsky
Feb 1, 1992·Diabetes Care·S L SuterJ M Olefsky
Nov 1, 1991·Diabetes Care·Y IwamotoI Shiraishi
Nov 1, 1991·Metabolism: Clinical and Experimental·T FujiwaraH Horikoshi
Jan 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·L T HoG M Reaven
Oct 1, 1990·Metabolism: Clinical and Experimental·T P CiaraldiK A Heidenreich
Feb 1, 1990·Diabetes/metabolism Reviews·W C KnowlerP H Bennett
Mar 1, 1990·Diabetes·S M HaffnerJ K Patterson
Apr 1, 1989·Metabolism: Clinical and Experimental·R A DeFronzoD C Simonson
Jul 1, 1989·Diabetes Care·M I Harris
Nov 1, 1988·Diabetes·T FujiwaraH Horikoshi
Dec 1, 1988·Diabetes·G M Reaven
Oct 1, 1984·The Journal of Clinical Investigation·C BogardusD Mott
Oct 1, 1981·The Journal of Clinical Investigation·O G KoltermanJ M Olefsky
Mar 1, 1994·Diabetes·M KellererH Häring
May 1, 1995·Diabetes Research and Clinical Practice·Y OhkuboM Shichiri
Mar 1, 1995·American Journal of Hypertension·T OgiharaK Masuo
Feb 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A A Lopes, F K Port
Jun 1, 1994·Diabetologia·D I PhillipsC Osmond
Jun 1, 1994·Diabetologia·R ValdezM P Stern
Nov 3, 1994·The New England Journal of Medicine·J J NolanJ Olefsky
Nov 3, 1994·The New England Journal of Medicine·H Keen
Nov 1, 1994·Endocrinology·J OhsumiN Serizawa
Dec 1, 1994·Diabetes·M K LeeJ M Olefsky
Dec 30, 1993·The New England Journal of Medicine·S LilliojaC Bogardus
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Apr 1, 1993·Journal of Diabetes and Its Complications·J S Yudkin
Feb 1, 1996·Diabetes Care·Y IwamotoT Kaneko
Dec 1, 1995·Metabolism: Clinical and Experimental·I InoueJ Ishii
Dec 1, 1996·Diabetes·A R Saltiel, J M Olefsky
Oct 1, 1996·Diabetes Research and Clinical Practice·R B Lipton
Mar 1, 1997·Diabetes·M N GhazziR W Whitcomb
Feb 1, 1997·Diabetes Care·S B HarrisB Zinman
Feb 1, 1997·Diabetes Care·T AntonucciR M Norris
Citations
Oct 24, 2002·Advanced Drug Delivery Reviews·Janice C Parker
Mar 29, 2001·Current Hypertension Reports·F RamosR Sánchez
Mar 23, 2002·Experimental Gerontology·Tami Wolden-HansonAlvin M Matsumoto
Mar 27, 2002·The Pharmacogenomics Journal·B E Rothberg
Nov 9, 2012·Expert Opinion on Drug Safety·Michele BortoliniBogdana Balas
Aug 26, 2010·British Journal of Pharmacology·E BjörklundC J Fowler
Dec 29, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Timothy Schulz-UtermoehlIan D Wilson
Aug 30, 2008·Journal of the American College of Cardiology·Gabriela OrasanuJorge Plutzky
Mar 17, 1999·Molecular Cell·Z WuB M Spiegelman
Oct 30, 1998·The Annals of Pharmacotherapy·C G Fraser, L Fierro
Oct 30, 1998·The Annals of Pharmacotherapy·S G TerraD B May
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·A AljadaP Dandona
Feb 16, 2018·PloS One·Ryota SugimotoKengo Suzuki
Jun 4, 1999·Drug Discovery Today·H Shinkai