Troglitazone suppresses intimal formation following balloon injury in insulin-resistant Zucker fatty rats

Atherosclerosis
E ShinoharaY Matsuzawa

Abstract

Troglitazone, a thiazolidinedione derivative, overcomes insulin resistance through promoting insulin receptor function. However, the effect of the resultant enhancement of insulin action on the regulation of cellular proliferation remains unknown. We investigated the effect of troglitazone on intimal proliferation after balloon injury in insulin-resistant Zucker fatty rats. Troglitazone markedly decreased blood glucose and triglyceride levels at the therapeutic dosage. The area of neointima significantly decreased in treated animals 2 weeks after operation, as compared with the untreated control animals (0.0526 +/- 0.0292 and 0.115 +/- 0.0354 mm2, respectively). The ratio of neointimal to medial area in treated rats (0.75 +/- 0.26) decreased by as much as 53% compared with untreated rats (1.40 +/- 0.05). We next examined DNA synthesis in cultured smooth muscle cells (SMCs) derived from non-insulin-resistant rats, to assess whether troglitazone suppresses the proliferation of vascular SMCs independent of metabolic effects. The result showed that troglitazone decreased [methyl-3H]thymidine incorporation into DNA. In conclusion, treatment with troglitazone in Zucker fatty rats resulted in a reduction in neointima formation after b...Continue Reading

References

Aug 22, 1992·Lancet·R J Jarrett
Aug 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B PfeifleH Ditschuneit
May 1, 1983·Experimental and Clinical Endocrinology·B Pfeifle, H Ditschuneit
Jan 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J J AlbersA Steinmetz
Nov 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K LippelG Vahouny

❮ Previous
Next ❯

Citations

Jan 12, 1999·Microvascular Research·D VranesR J Dilley
Mar 8, 2005·Current Hypertension Reports·Ligia J Dominguez, James R Sowers
May 27, 2005·The Journal of Surgical Research·Panagiotis KougiasChangyi Chen
Sep 19, 2001·Current Opinion in Lipidology·K J MooreM W Freeman
Feb 8, 2006·Canadian Journal of Physiology and Pharmacology·Jarmila MachackovaNaranjan S Dhalla
Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Akiko HiguchiNoriyuki Ouchi
Sep 7, 2000·The Journal of Clinical Investigation·E D Rosen, B M Spiegelman
Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·A SugawaraS Ito
Feb 20, 2007·The American Journal of Cardiology·Gabriel I Uwaifo, Robert E Ratner
Dec 18, 2003·The American Journal of Medicine·Dennis Bruemmer, Ronald E Law
Jul 2, 2005·Expert Opinion on Emerging Drugs·J Linde, B H Strauss
Apr 1, 2008·Biochemical and Biophysical Research Communications·Bonnie L GoodwinDuane C Eichler
Jul 6, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohammad NewazAdebayo Oyekan
May 10, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·Behzad MolaviJawahar L Mehta
Mar 29, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Katherine M HannanPeter J Little
Sep 23, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Kent StephensonHayes M Dansky
Feb 16, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D BruemmerR E Law
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Jinah HwangC Michael Hart
Jan 3, 2001·Nature Medicine·K J MooreM W Freeman
Aug 10, 2000·Medicinal Research Reviews·K W Buchan, D G Hassall
Sep 15, 2001·The Journal of Biological Chemistry·H VosperC N Palmer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.