Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro

Kidney International
R E RouthK J McCarthy

Abstract

Our laboratory has shown that troglitazone, a thiazolidinedione and peroxisomal proliferator activated receptor gamma (PPAR-gamma) agonist, prevents mesangial expansion and glomerulosclerosis in diabetic rats. We investigated and compared the action of two PPAR agonists at the level of the mesangial cell. Rat mesangial cells were grown in medium containing 5 mmol/L glucose, 30 mmol/L glucose, or 5 mmol/L glucose plus 25 mmol/L mannitol. The cultures were either left untreated, treated with 10 micromol/L troglitazone (PPAR-gamma), or 100 micromol/L clofibrate (PPAR-alpha). The following parameters were used to assess mesangial cell responses: detection of PPAR-gamma and -alpha mRNA, the degree of PPAR-gamma and -alpha activation, spread cell area, total protein production, and laminin and type I collagen production. Reverse transcription-polymerase chain reaction (RT-PCR) showed the presence of PPAR-gamma and -alpha mRNA in rat mesangial cells. PPAR-gamma and -alpha proteins are active in mesangial cells and the extent of activation is affected by different glycemic conditions. Troglitazone and clofibrate treatment corrected in part the increase in spread cell area seen in mesangial cells in hyperglycemic conditions. However, ne...Continue Reading

References

Dec 1, 1992·Human Pathology·A D GlickM A Haralson
Aug 1, 1972·American Journal of Clinical Pathology·R P Misra
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarM L Jakubowski
Nov 1, 1994·Journal of the American Society of Nephrology : JASN·S Adler
Jun 1, 1994·Kidney International·R J Johnson
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerR M Evans
Jun 1, 1996·Kidney International·H D RupprechtR B Sterzel
Oct 15, 1996·The Journal of Clinical Investigation·R E LawW A Hsueh
Oct 1, 1996·Diabetes/metabolism Reviews·R Osterby
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerJ M Lehmann
Jul 25, 1997·The Journal of Biological Chemistry·L FajasJ Auwerx
Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·B R Zimmerman
Nov 5, 1997·Kidney International·O S BetterJ P Knochel
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·T S HaB S Kasinath
Mar 1, 2000·British Journal of Pharmacology·D Bishop-Bailey
Mar 22, 2000·Metabolism: Clinical and Experimental·S OgawaT Sato
Sep 2, 2000·The Journal of Biological Chemistry·T MiyaharaH Tsukamoto
Dec 15, 2000·Kidney International·K J McCarthyJ H Johnson
Feb 28, 2001·Diabetes, Obesity & Metabolism·S A SmithR E Buckingham
Jun 8, 2001·Annual Review of Biochemistry·T M WillsonS A Kliewer

❮ Previous
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Citations

Dec 1, 2005·Current Diabetes Reports·Yahua Zhang, Youfei Guan
Aug 26, 2006·Nature Clinical Practice. Nephrology·Usha PanchapakesanCarol A Pollock
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Sunil AsnaniVivian A Fonseca
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing XiaoKar Neng Lai
Jan 18, 2008·Nephrology·Priscilla Kincaid-SmithJoseph Proietto
Dec 1, 2005·Kidney International·Xiong Z RuanJohn F Moorhead
Jun 18, 2011·The Journal of Endocrinology·Victor P BilanStevan P Tofovic
May 15, 2007·Kidney International·M LauerK J McCarthy
May 16, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jing XiaoKar Neng Lai
Jul 17, 2013·Experimental Biology and Medicine·Asish K GhoshDouglas E Vaughan
Nov 6, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Mark E Lauer, Kevin J McCarthy
Apr 3, 2003·Molecular & Cellular Proteomics : MCP·Teresa KuncewiczBruce C Kone
May 9, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue-Jing LiuWei Huang
Jan 7, 2010·Journal of Korean Medical Science·Jee-Young HanDae-Ryong Cha
Aug 2, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Henri BoulangerDenis Glotz
Nov 13, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Toru KawaiNoriaki Yorioka
Dec 29, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jami E MilamRaju C Reddy
Feb 1, 2008·American Journal of Physiology. Renal Physiology·Xiongzhong RuanYoufei Guan
Sep 25, 2019·Nature Reviews. Drug Discovery·Xiao ZhaoFei-Fei Liu
Apr 29, 2004·American Journal of Physiology. Renal Physiology·U PanchapakesanX M Chen
Oct 16, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anping Chen, Jianye Xu
May 12, 2005·American Journal of Physiology. Renal Physiology·U PanchapakesanX Chen
Oct 16, 2007·Arquivos brasileiros de endocrinologia e metabologia·Claudia J LagranhaMaria Claudia Irigoyen
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Greg CoatesTomas Welbourne

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