PMID: 7514085Mar 7, 1994Paper

Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA

Brain Research
H S ChowD W Choi

Abstract

The vitamin E analog, trolox, protected cultured cortical neurons against damage induced by exposure to either iron ions or ultraviolet (UV) light, consistent with an ability to inhibit free radical-mediated cytotoxicity. Trolox also reduced neuronal death induced by 24 h exposure to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), but not that induced by N-methyl-D-aspartate (NMDA). When combined with the NMDA receptor antagonist dextrorphan, trolox also reduced the neuronal injury induced by glucose deprivation.

References

Dec 1, 1991·The Journal of Investigative Dermatology·R OguraN Haramaki
Feb 1, 1991·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·L H ZengT W Wu
Apr 1, 1989·The Annals of Thoracic Surgery·D A MickleK U Ingold
Dec 1, 1988·Journal of Neurochemistry·D E Pellegrini-GiampietroF Moroni
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·D K Anderson, E D Means
Jan 1, 1985·British Journal of Anaesthesia·B MeldrumR Simon
Jan 1, 1984·Journal of Neurochemistry·B D WatsonM D Ginsberg

❮ Previous
Next ❯

Citations

Dec 25, 2002·Journal of Neurosurgical Anesthesiology·Megumi HashimotoKiyoshi Morita
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·L L DuganT S Lin
Jun 6, 2003·Journal of Neurochemistry·Duncan G MacGregorMargaret E Rice
Jun 18, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Babasaheb P BandgarShivraj H Nile
May 15, 2015·Human Molecular Genetics·Silvia Olivera-BravoLuis Barbeito
Feb 11, 2000·Annals of the New York Academy of Sciences·S D SkaperP Giusti
Sep 18, 1997·Plastic and Reconstructive Surgery·E F RitterB Klitzman
Feb 4, 1999·Journal of Neurochemistry·J Y KohJ H Seo
Sep 1, 1996·Chemistry & Biology·W J ScheenenR Y Tsien
Feb 6, 2008·Bioorganic & Medicinal Chemistry Letters·Tae-Souk KangYoung-Sik Jung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.