Tromboelastography: variability and relation to conventional coagulation test in non-bleeding intensive care unit patients

BMC Anesthesiology
Jørgen Holli HalsetPål Klepstad

Abstract

Intensive care unit (ICU) patients usually have abnormal biochemical and hematological laboratory test results as a consequence of organ dysfunction and underlying disease. Thromboelastography (TEG®) is a point-of-care laboratory analysis that gives an overview of several aspects of the coagulation process. In order to be able to perform a clinical interpretation of abnormal TEG® results the expected values from non-bleeding ICU patients should be known. The aim of this study is to report the normal variability observed in non-bleeding, non-transfused ICU patients. Adult ICU patients without bleeding in the last 24 hours, who had not received blood products within the last 24 hours, with no hematological diseases and no anticoagulation therapeutic treatment were included. Standard clinical chemistry tests, coagulation tests and TEG® were obtained. All results were reported in relation to standard reference values. TEG® values were compared with routine coagulation measurement using Spearman correlations. We observed that the normal variability observed in non-bleeding, non-transfused ICU patients in this study included abnormally high TEG® values for maximum amplitude (MA) (73%). None of the patients showed MA results correspon...Continue Reading

References

Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Feb 11, 1999·Anesthesia and Analgesia·L Shore-LessersonM A Ergin
Oct 26, 2000·Anesthesia and Analgesia·H J GortonM O Columb
Sep 28, 2002·Anesthesia and Analgesia·Miriam J P HarnettLawrence C Tsen
Jul 24, 2004·Anesthesia and Analgesia·Kwok F J Ng
Mar 24, 2005·Clinical and Laboratory Haematology·R J Luddington
Aug 4, 2007·American Journal of Respiratory and Critical Care Medicine·Delphine BorgelJean-Luc Diehl
Nov 3, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S ScarpeliniS B Rizoli
Feb 18, 2010·Transfusion·Wilfried W H RoeloffzenJoost Th M de Wolf
Feb 19, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Louise BochsenSisse R Ostrowski
Oct 28, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Sisse R OstrowskiPär I Johansson
Feb 12, 2014·Critical Care : the Official Journal of the Critical Care Forum·Marcella C MüllerNicole P Juffermans

❮ Previous
Next ❯

Citations

Mar 9, 2017·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Aurora Espinosa, Marit Seim Ekeland
Aug 24, 2019·Journal of Clinical Laboratory Analysis·Xun WangJin Zhang
Jul 4, 2020·Critical Care Medicine·Eugene YuriditskyJeffrey S Berger
Apr 30, 2019·The Journal of Trauma and Acute Care Surgery·Niluka WickramaratneMartin J Mangino
Nov 16, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Lene RussellAnders Perner
Dec 25, 2015·World Journal of Emergency Medicine·Jun-Ping ChenShi-Hai Zhang
Apr 13, 2021·Military Medical Research·Jing-Chun SongUNKNOWN Chinese People’s Liberation Army Professional Committee of Critical Care Medicine and Chinese Society of Thrombosis, Hemosta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.