TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling

Molecular Medicine Reports
Qing-Zhi GuZheng Tian

Abstract

Human trophoblast cell surface antigen 2 (TROP2) has been noted to serve an important role in the proliferation and migration of various types of human cancers. However, the potential role and the molecular mechanisms of TROP2 in osteosarcoma (OS) remain largely unclear. In the present study, high expression of TROP2 in human OS tissues and cell lines was observed. Overexpression of TROP2 promoted the proliferation and migration of OS cell lines, while TROP2 knockdown markedly decreased cell growth and migration. Furthermore, it was revealed that TROP2 overexpression significantly activated the phosphoinositide 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway. Collectively, these results suggested that TROP2 may promote OS cell proliferation and migration via PI3K/AKT signaling and may serve as a novel treatment target for OS.

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Citations

Nov 15, 2020·Cancers·Sára LenártPetr Beneš
Jun 10, 2021·Clinical, Cosmetic and Investigational Dermatology·Azza Gaber Antar FaragAmal Farid Mostafa
Sep 18, 2021·Journal of Cancer Research and Clinical Oncology·Shota OmoriToshiaki Takahashi

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