Trophic factor expression in phrenic motor neurons.

Respiratory Physiology & Neurobiology
Carlos B Mantilla, Gary C Sieck

Abstract

The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation. DIAm motor units are capable of both ventilatory and non-ventilatory behaviors, including expulsive behaviors important for airway clearance. There is significant diversity in motor unit properties across different types of motor units in the DIAm. The mechanisms underlying the development and maintenance of motor unit diversity in respiratory muscles (including the DIAm) are not well understood. Recent studies suggest that trophic factor influences contribute to this diversity. Remarkably little is known about the expression of trophic factors and their receptors in phrenic motor neurons. This review will focus on the contribution of trophic factors to the establishment and maintenance of motor unit diversity in the DIAm, during development and in response to injury or disease.

References

May 2, 1979·Experimental Brain Research·C L WebberJ M Chung
Nov 1, 1992·Journal of Neurobiology·V Hamburger
Dec 22, 1990·The Journal of Comparative Neurology·H H EllenbergerH G Goshgarian
Dec 22, 1991·The Journal of Comparative Neurology·W E CameronR D Guthrie
Aug 1, 1991·Journal of Applied Physiology·G C SieckC E Blanco
Jan 1, 1990·Brain Research. Developmental Brain Research·W E CameronR D Guthrie
Feb 13, 1989·Neuroscience Letters·G C SieckJ G Enad
Jun 1, 1989·Journal of Applied Physiology·G C Sieck, M Fournier
Dec 1, 1986·Journal of Applied Physiology·F J Kong, A J Berger
Mar 1, 1988·The Journal of Comparative Neurology·H H Ellenberger, J L Feldman
Mar 1, 1988·Journal of Neurophysiology·M Fournier, G C Sieck
Sep 1, 1994·The Journal of Comparative Neurology·E G Dobbins, J L Feldman
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Jul 1, 1994·Journal of Applied Physiology·B D JohnsonG C Sieck
Sep 1, 1993·Journal of Applied Physiology·Y S PrakashG C Sieck
Dec 1, 1993·Journal of Neurobiology·Q YanW D Snider
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J FrisénD Lindholm
Jun 1, 1996·Journal of Applied Physiology·G C SieckC E Blanco
Jun 1, 1997·Experimental Brain Research·E Hensbergen, D Kernell
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M CanossaH Thoenen

❮ Previous
Next ❯

Citations

Nov 5, 2013·The Journal of Physiology·Gary C Sieck, Carlos B Mantilla
Jan 30, 2015·The Journal of Physiology·Sarah M GreisingCarlos B Mantilla
Sep 12, 2009·Respiratory Physiology & Neurobiology·Carlos B Mantilla, Gary C Sieck
Aug 26, 2009·Respiratory Physiology & Neurobiology·Gary C Sieck, Carlos B Mantilla
Aug 30, 2008·Respiratory Physiology & Neurobiology·Donald R McCrimmonGeorge F Alheid
Jul 30, 2015·Respiratory Physiology & Neurobiology·Ryan W BavisAmy B McDonough
Jul 20, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Sarah M GreisingGary C Sieck
Sep 30, 2010·The Journal of Comparative Neurology·Amine N IssaCarlos B Mantilla
Nov 28, 2012·Muscle & Nerve·Kirkwood E Personius, Sara D Parker
Nov 10, 2018·The Journal of Comparative Neurology·Carlos B MantillaGary C Sieck
Apr 11, 2019·Physiology·Joline E BrandenburgGary C Sieck
May 3, 2018·Journal of Neurophysiology·Joline E BrandenburgGary C Sieck
Jan 17, 2020·Journal of Applied Physiology·Miguel Pareja-CajiaoCarlos B Mantilla
Aug 30, 2014·Journal of Applied Physiology·Carlos B MantillaGary C Sieck
Nov 3, 2020·Journal of Pediatric Rehabilitation Medicine·Joline E BrandenburgGary C Sieck
Feb 19, 2021·Journal of Neurophysiology·Miguel Pareja-CajiaoCarlos B Mantilla

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved