PMID: 9416353Jan 1, 1997Paper

Trophoblast cell-mediated modifications to uterine spiral arteries during early gestation in the macaque

Acta Anatomica
T N Blankenship, A C Enders

Abstract

A specialized subset of invasive embryonic cytotrophoblast cells gains access to maternal uterine arteries early in the gestation of higher primates. These cells continue to migrate extensively within the lumina of spiral arteries, converting them to the highly modified uteroplacental arteries of pregnancy. Although trophoblast cell-mediated modifications are considered critical to the progress of normal pregnancy, few studies have addressed the cellular interactions between maternal arteries and embryonic cells in situ. Macaque placentas and endometrial tissues were collected from 12 animals from day 14 of gestation (blastocyst implantation begins on day 9) to day 49. Standard indirect immunoperoxidase methods were used to identify matrix metalloproteinases (MMP-1, MMP-3, MMP-9), cathepsin B, cathepsin D, platelet-endothelial cell adhesion molecule, cytokeratins, smooth muscle actin, CD68, and factor VIII-related antigen. Cytotrophoblast cells were located deep within spiral arteries in each of the specimens examined. In some examples tightly packed clusters of cytotrophoblast occluded the lumina of invaded arteries. Initial penetration of arterial tunica intima was revealed by discontinuities in the staining pattern for facto...Continue Reading

Citations

Jan 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aikaterini VaranouMyriam Hemberger
Apr 9, 2005·Experimental Cell Research·Twanda L ThirkillGordon C Douglas
Jul 10, 2003·Clinical Biochemistry·Abdelaziz KharfiJean-Claude Forest
Nov 18, 1998·Current Opinion in Cell Biology·C H Damsky, S J Fisher
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·I I SlukvinT G Golos
May 26, 2007·The American Journal of Pathology·Guy St J WhitleyJudith E Cartwright
Jan 24, 2008·American Journal of Reproductive Immunology : AJRI·Tim C CaoGordon C Douglas
Jul 5, 2001·The American Journal of Pathology·D IlićS J Fisher
Jul 8, 2014·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hironori TakahashiToshihiro Takizawa
Apr 12, 2002·Placenta·J E CartwrightG St J Whitley
May 29, 2002·Biochimica Et Biophysica Acta·Arlen SoghomoniansGordon C Douglas
Aug 12, 2016·Histochemistry and Cell Biology·Gregor WeissGerit Moser
Mar 4, 2005·Biology of Reproduction·Arlen SoghomoniansGordon C Douglas
Dec 14, 2004·Human Fertility : Journal of the British Fertility Society·Sheba Anin AninSiobhan Quenby
Feb 5, 2003·Microscopy Research and Technique·Thomas N Blankenship, Allen C Enders
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gennadiy I BondarenkoThaddeus G Golos
Mar 31, 2009·Colloids and Surfaces. B, Biointerfaces·Wanqian LiuNa Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.