Trophoblast gene expression: transcription factors in the specification of early trophoblast

Reproductive Biology and Endocrinology : RB&E
R Michael RobertsPadmalaya Das

Abstract

Azone of trophoblast specification is established when the embryo is a morula, presumably reflecting a unique combination of transcription factors in that zone of cells and the influence of various environmental cues and growth factors on them. A key first step in this process of specification is the down-regulation of Oct4, a transcription factor that acts as a negative regulator of trophoblast specification and of genes normally up-regulated as the trophectoderm first forms. The transcription factors believed to have a positive association with trophectoderm specification have been inferred primarily in two ways: by their expression patterns in embryos, ES cells and TS cells and by the consequences of gene disruption on embryonic development. Many of these transcription factors also control the expression of genes characteristically expressed in trophoblast but not in the epiblast, primitive endoderm and their derivatives. ES and TS cells from the mouse and other species are beginning to provide insights into the changes in gene expression that accompany lineage specification and the subsequent post-specification events that lead to functional trophoblast derivatives.

References

Jan 11, 1992·Reproduction, Fertility, and Development·R D GeisertM T Zavy
Mar 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Roberts
Feb 1, 1990·Endocrine Reviews·G E Ringler, J F Strauss
Aug 1, 1986·Developmental Biology·M IzharM N Fukuda
Jul 1, 1985·Journal of Reproduction and Fertility·J D GodkinR M Roberts
Jul 1, 1980·Placenta·D H StevenP W Nathanielsz
Jan 1, 1994·Reproduction, Fertility, and Development·M B Wheeler
Jan 13, 1995·Science·B FeldmanM Goldfarb
Sep 1, 1993·The Journal of Experimental Zoology·L H Hoffman, F B Wooding
Sep 1, 1995·Molecular Reproduction and Development·N C TalbotC E Rexroad
Nov 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F BeckR James
Jan 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y JenR Benezra
Mar 6, 1997·Nature·K ChawengsaksophakF Beck
Nov 22, 1997·Biology of Reproduction·H ShimG B Anderson
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·E ArmanP Lonai
Jun 6, 1998·Genes & Development·H YamamotoR G Oshima
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·T EzashiR M Roberts
Oct 15, 1998·Molecular Reproduction and Development·D A RappoleeK Jacobson
Nov 6, 1998·Science·J A ThomsonJ M Jones
Dec 16, 1998·Science·S TanakaJ Rossant
Feb 18, 1999·The EMBO Journal·M Schorpp-KistnerE F Wagner
Apr 20, 1999·Biology of Reproduction·M J van EijkF Gandolfi
May 20, 1999·Mechanisms of Development·S N HancockV E Papaioannou
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B Nait-OumesmarR A Lazzarini
Aug 15, 2000·Molecular and Cellular Endocrinology·W Johnson, J L Jameson
Oct 25, 2000·Molecular Human Reproduction·C HansisL C Krey
Nov 25, 2000·Biology of Reproduction·N KirchhofH Niemann
Mar 21, 2001·Seminars in Reproductive Medicine·J M Jones, J A Thomson
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·M Hemberger, J C Cross

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Citations

Nov 25, 2005·Stem Cells and Development·Kaisa L SelesniemiThomas L Brown
Nov 15, 2007·Stem Cells and Development·Catherine A VandevoortGordon C Douglas
Nov 26, 2010·Biology of Reproduction·R Michael Roberts, Susan J Fisher
Jul 20, 2007·Molecular and Cellular Biology·Atsushi P KimuraStephen A Liebhaber
Mar 7, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·D A RappoleeY Xie
Nov 11, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Flavia N T CookeAlan D Ealy
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Guillaume JunionKrzysztof Jagla
Feb 6, 2017·General and Comparative Endocrinology·Brad M ReinholtSally E Johnson
Jun 9, 2017·International Journal of Molecular Sciences·Marta MajewskaBozena Szafranska
Nov 18, 2005·Developmental Biology·Séverine A DegrelleIsabelle Hue
Mar 3, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Elina V GarcíaDimitrios Rizos
Jul 10, 2013·Molecular Reproduction and Development·Andrew T Schiffmacher, Carol L Keefer
Sep 11, 2020·Life Science Alliance·Sarbani Saha, Rupasri Ain
Jan 9, 2019·Acta histochemica·Grzegorz PanasiewiczBozena Szafranska
Aug 6, 2021·Frontiers in Veterinary Science·Sharon ArcuriTiziana A L Brevini

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