Trophoblast transferrin and transferrin receptors in the host--parasite relationship of human pregnancy

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
W Page Faulk, G M Galbraith

Abstract

Transferrin and specific transferrin receptors are demonstrated on the microvillous surface of syncytiotrophoblast in human immature and term placentae by immuno histological techniques with the use of light and electron microscopy. That the distribution of transferrin is limited to the materno-foetal interface supports the hypothesis that binding of maternal transferrin to trophoblast receptors is involved in the process of iron transport to the foetus. Parallel studies with baboon placentae demonstrate the presence of trophoblast receptors which bind both baboon and human transferrin, thereby putting forward an experimental model which might be used to test the biological significance of placental transferrin receptors in primates. In addition, investigation of a large number of human cell lines shows that many transformed cells, but no normal cells (such as blood lymphocytes) or cells from primary culture (such as neonatal foreskin fibroblasts), possess the ability to bind transferrin to their membranes. These findings suggest that transferrin receptors may play important biological roles in addition to that of iron transport from mother to foetus. One such role could be the limitation of iron in intervillous spaces, thus de...Continue Reading

References

Apr 13, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M E Bramwell, H Harris
Jan 1, 1976·Cellular Immunology·B H Waksman, Y Namba
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·P HerseyW H McCarthy
Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·M ZöllerR W Baldwin
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W P FaulkN Smith
Apr 30, 1976·Biochimica Et Biophysica Acta·R O Hynes
May 1, 1977·British Journal of Haematology·D Hemmaplardh, E H Morgan
Jul 1, 1977·European Journal of Pediatrics·G Zoppi, G Zamboni
Oct 1, 1977·Experimental Parasitology·O L GoldringS R Smithers
Sep 20, 1976·Biochemical and Biophysical Research Communications·J L Phillips
Dec 1, 1976·The Journal of Experimental Medicine·J L Van Snick, P L Masson
Jul 10, 1975·Nature·W P FaulkM Papamichail
Jan 15, 1975·International Journal of Cancer. Journal International Du Cancer·I Hellström, K E Hellström
Jan 6, 1975·JAMA : the Journal of the American Medical Association·E D Weinberg
Jan 1, 1971·The Journal of Experimental Medicine·J N McCormickH H Fudenberg
Aug 24, 1974·Lancet·O A Okubadejo
Sep 7, 1974·Lancet·J Braeman
Dec 28, 1974·Lancet·R S Stein
Apr 1, 1967·Lancet·G A Currie, K D Bagshawe
Sep 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T E MasonR B Dreskin
Sep 1, 1974·Infection and Immunity·J J BullenS N Wallis
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R M FauveF Jacob
May 26, 1971·Nature: New Biology·W P FaulkK Chism
Feb 25, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S R SmithersD J Hockley
May 31, 1974·Science·E D Weinberg
Sep 1, 1972·Experimental Cell Research·D C TormeyG C Mueller
Sep 1, 1973·Journal of Clinical Pathology·W N Ramsay
Sep 1, 1973·Clinical Science and Molecular Medicine·S R LynchR W Charlton
May 1, 1974·The Journal of Pediatrics·C KattamisN Matsaniotis
Jul 1, 1974·Experimental Cell Research·D Hemmaplardh, E H Morgan
Sep 1, 1972·Experimental Cell Research·D C Tormey, G C Mueller
Nov 1, 1971·Acta paediatrica Scandinavica·E J TomsovicH H Fudenberg
Apr 1, 1969·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·E Baker, E H Morgan
Jan 1, 1970·Transactions of the Royal Society of Tropical Medicine and Hygiene·L G Goodwin
Jun 29, 1968·Nature·J Fletcher, E R Huehns
Nov 1, 1966·Transplantation·D R KirbyD A James
Apr 1, 1958·The Journal of Pathology and Bacteriology·W W PARK
Aug 28, 1959·Annals of the New York Academy of Sciences·W A BARDAWIL, B L TOY
Aug 1, 1963·Virology·H F CLARK, C C SHEPARD
Mar 26, 1964·The New England Journal of Medicine·R E BILLINGHAM
Oct 1, 1964·The Journal of Clinical Investigation·D GITLINC MORALES

❮ Previous
Next ❯

Citations

Mar 1, 1981·Biological Trace Element Research·E D Weinberg
Jan 1, 1986·The International Journal of Biochemistry·B KhalfounP Bardos
May 1, 1987·Journal of Reproductive Immunology·J S HuntG W Wood
Nov 1, 1987·Journal of Reproductive Immunology·B L HsiP L Stern
Jan 1, 1993·Journal of Reproductive Immunology·C J ThalerW P Faulk
Jun 2, 2005·Journal of Autoimmunity·John A McIntyreW Page Faulk
May 31, 1980·Lancet·W P FaulkB L Hsi
Oct 10, 1985·The New England Journal of Medicine·L R Weitkamp, B Z Schacter
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A McIntyre, W P Faulk
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I S Trowbridge, M B Omary
Jan 1, 1983·Nutrition and Cancer·E D Weinberg
Apr 1, 1991·American Journal of Reproductive Immunology : AJRI·C B CoulamJ A McIntyre
Apr 1, 1992·American Journal of Reproductive Immunology : AJRI·J A SizenskyW P Faulk
Dec 1, 1983·Journal of Clinical Pathology·M WellsW P Faulk
Mar 1, 1981·Clinics in Endocrinology and Metabolism·H Fox, W P Faulk
Aug 1, 1980·Clinical Immunology and Immunopathology·G M GalbraithR M Galbraith
Nov 1, 1989·American Journal of Reproductive Immunology : AJRI·W P Faulk, J S Hunt
Jan 1, 1980·American Journal of Reproductive Immunology : AJRI·P M Johnson, P J Brown
Oct 1, 1980·British Journal of Haematology·K NishiyaM De Sousa
Jan 1, 1983·Immunological Reviews·W P Faulk, J A McIntyre
Dec 13, 2005·Autoimmunity Reviews·John A McIntyreW Page Faulk
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·R M GalbraithW P Faulk
Nov 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Wedekind
Sep 1, 1982·Journal of Cellular Physiology·I S TrowbridgeR Schulte
Jan 1, 1980·Archives of Oto-rhino-laryngology·E K PedersenH H Elverland
Jun 1, 1983·American Journal of Reproductive Immunology : AJRI·C J BramiF Naftolin
Apr 1, 1991·American Journal of Reproductive Immunology : AJRI·K BarabasW P Faulk
Dec 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·D DegenneP Bardos
Nov 1, 1989·American Journal of Reproductive Immunology : AJRI·W P FaulkF L Crane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
W Page FaulkN C Smith
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
W Page FaulkM Ueda
© 2021 Meta ULC. All rights reserved